Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

V. I. Krylov; S. V. Moiseev; A. A. Kutin; N. G. Sakhno; O. V. Gunar; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1379-0

Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

Авторы: Krylov V.I.¹, Moiseev S.V.¹, Kutin A.A.¹, Sakhno N.G.¹, Gunar O.V.¹, Yashkir V.A.¹, Merkulov V.A.¹
Учреждения:
1. Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Выпуск: Том 49, № 12 (2016)
Страницы: 821-824
Раздел: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244300
DOI: https://doi.org/10.1007/s11094-016-1379-0
ID: 244300

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Аннотация

An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.