Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

V. I. Krylov; S. V. Moiseev; A. A. Kutin; N. G. Sakhno; O. V. Gunar; V. A. Yashkir; V. A. Merkulov

doi:10.1007/s11094-016-1379-0

Synthesis and Antibacterial Activity of Bis-[1-(Adamantan-1-Yl)Ethyl]Amine Hydrochloride

Авторлар: Krylov V.I.¹, Moiseev S.V.¹, Kutin A.A.¹, Sakhno N.G.¹, Gunar O.V.¹, Yashkir V.A.¹, Merkulov V.A.¹
Мекемелер:
1. Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Шығарылым: Том 49, № 12 (2016)
Беттер: 821-824
Бөлім: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244300
DOI: https://doi.org/10.1007/s11094-016-1379-0
ID: 244300

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

An impurity in rimantadine hydrochloride drug substance that was previously undescribed in regulatory documents and the literature was identified. Its structure was elucidated and confirmed by a convergent synthesis. A method for synthesizing bis-[1-(adamantan-1-yl)ethyl]amine hydrochloride under laboratory conditions was developed. The antibacterial activity of the synthesized compound was assessed.