Enviar artigo por via de e-mail Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide
- Autores: Rodina T.A.1,2, Mel’nikov E.S.3,2, Sokolov A.V.1,3, Prokof’ev A.B.1,3,2, Arkhipov V.V.1,3,2, Aksenov A.A.3, Pozdnyakov D.L.2
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Afiliações:
- Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation
- I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
- I. M. Sechenov First Moscow State Medical University
- Edição: Volume 50, Nº 6 (2016)
- Páginas: 419-423
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244408
- DOI: https://doi.org/10.1007/s11094-016-1462-6
- ID: 244408
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Resumo
A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 – 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 – 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.
Sobre autores
T. Rodina
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Rússia, Moscow, 127051; Moscow, 109240
E. Mel’nikov
I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Rússia, Moscow, 119991; Moscow, 109240
A. Sokolov
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Rússia, Moscow, 127051; Moscow, 119991
A. Prokof’ev
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Rússia, Moscow, 127051; Moscow, 119991; Moscow, 109240
V. Arkhipov
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Rússia, Moscow, 127051; Moscow, 119991; Moscow, 109240
A. Aksenov
I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Rússia, Moscow, 119991
D. Pozdnyakov
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Rússia, Moscow, 109240
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