Отправить статью по E-mail Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide
- Авторы: Rodina T.A.1,2, Mel’nikov E.S.3,2, Sokolov A.V.1,3, Prokof’ev A.B.1,3,2, Arkhipov V.V.1,3,2, Aksenov A.A.3, Pozdnyakov D.L.2
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Учреждения:
- Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation
- I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
- I. M. Sechenov First Moscow State Medical University
- Выпуск: Том 50, № 6 (2016)
- Страницы: 419-423
- Раздел: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244408
- DOI: https://doi.org/10.1007/s11094-016-1462-6
- ID: 244408
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Аннотация
A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 – 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 – 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.
Об авторах
T. Rodina
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Россия, Moscow, 127051; Moscow, 109240
E. Mel’nikov
I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Россия, Moscow, 119991; Moscow, 109240
A. Sokolov
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Россия, Moscow, 127051; Moscow, 119991
A. Prokof’ev
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Россия, Moscow, 127051; Moscow, 119991; Moscow, 109240
V. Arkhipov
Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Россия, Moscow, 127051; Moscow, 119991; Moscow, 109240
A. Aksenov
I. M. Sechenov First Moscow State Medical University
Email: chem@folium.ru
Россия, Moscow, 119991
D. Pozdnyakov
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Россия, Moscow, 109240
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