Synthesis and Biological Properties of {[(4-Hydroxy-1-Methyl-2,2-Dioxido-1H-2,1-Benzothiazin-3-YL)Carbonyl]Amino}-Benzoic Acids and Their Derivatives


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Аннотация

Continuing the search for novel biologically active substances among the 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides series, we report here the synthesis of a series of {[(4-hydroxy-1-methyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)carbonyl]amino} benzoic acids asd their derivatives at the carboxyl group. Pharmacological testing showed that compounds with a free carboxyl group are of interest as potential diuretics, while carbamide derivatives have potential as analgesics. Esterification of the carboxyl group with lower alkyl alcohols was less effective.

Авторлар туралы

I. Ukrainets

National Pharmaceutical University

Email: chem@folium.ru
Украина, Kharkov

L. Petrushova

Vinnitsa N. I. Pirogov National Medical University

Email: chem@folium.ru
Украина, Vinnitsa

S. Dzyubenko

Far East State Medical University

Email: chem@folium.ru
Ресей, Khabarovsk

L. Grinevich

National Pharmaceutical University

Email: chem@folium.ru
Украина, Kharkov

G. Sim

Far East State Medical University

Email: chem@folium.ru
Ресей, Khabarovsk

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