Synthesis and Biological Properties of {[(4-Hydroxy-1-Methyl-2,2-Dioxido-1H-2,1-Benzothiazin-3-YL)Carbonyl]Amino}-Benzoic Acids and Their Derivatives
- 作者: Ukrainets I.V.1, Petrushova L.A.2, Dzyubenko S.P.3, Grinevich L.A.1, Sim G.3
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隶属关系:
- National Pharmaceutical University
- Vinnitsa N. I. Pirogov National Medical University
- Far East State Medical University
- 期: 卷 51, 编号 7 (2017)
- 页面: 553-557
- 栏目: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244705
- DOI: https://doi.org/10.1007/s11094-017-1653-9
- ID: 244705
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详细
Continuing the search for novel biologically active substances among the 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides series, we report here the synthesis of a series of {[(4-hydroxy-1-methyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)carbonyl]amino} benzoic acids asd their derivatives at the carboxyl group. Pharmacological testing showed that compounds with a free carboxyl group are of interest as potential diuretics, while carbamide derivatives have potential as analgesics. Esterification of the carboxyl group with lower alkyl alcohols was less effective.
作者简介
I. Ukrainets
National Pharmaceutical University
Email: chem@folium.ru
乌克兰, Kharkov
L. Petrushova
Vinnitsa N. I. Pirogov National Medical University
Email: chem@folium.ru
乌克兰, Vinnitsa
S. Dzyubenko
Far East State Medical University
Email: chem@folium.ru
俄罗斯联邦, Khabarovsk
L. Grinevich
National Pharmaceutical University
Email: chem@folium.ru
乌克兰, Kharkov
G. Sim
Far East State Medical University
Email: chem@folium.ru
俄罗斯联邦, Khabarovsk
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