Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]Dodec-11-EN-4-YL)Ureas

B. A. Selivanov; A. Y. Tikhonov; E. F. Belanov; N. I. Bormotov; A. S. Kabanov; O. Yu. Mazurkov; O. A. Serova; L. N. Shishkina; A. P. Agafonov; A. N. Sergeev

doi:10.1007/s11094-017-1629-9

Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0^2,6.0^8,10]Dodec-11-EN-4-YL)Ureas

Авторлар: Selivanov B.A.¹, Tikhonov A.Y.¹, Belanov E.F.², Bormotov N.I.², Kabanov A.S.², Mazurkov O.Y.², Serova O.A.², Shishkina L.N.², Agafonov A.P.², Sergeev A.N.²
Мекемелер:
1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)
2. VECTOR State Research Center of Virology and Biotechnology
Шығарылым: Том 51, № 6 (2017)
Беттер: 439-443
Бөлім: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244643
DOI: https://doi.org/10.1007/s11094-017-1629-9
ID: 244643

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Аннотация
Авторлар туралы
Әдебиет тізімі
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Статистика

Аннотация

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.

Негізгі сөздер

arylisocyanates, arylisothiocyanates, 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)ureas, smallpox vaccines, antiviral activity, pharmacological activity

Авторлар туралы

B. Selivanov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Хат алмасуға жауапты Автор.
Email: seliboba@nioch.nsc.ru
Ресей, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090

A. Tikhonov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Email: seliboba@nioch.nsc.ru
Ресей, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090