Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]Dodec-11-EN-4-YL)Ureas

B. A. Selivanov; A. Y. Tikhonov; E. F. Belanov; N. I. Bormotov; A. S. Kabanov; O. Yu. Mazurkov; O. A. Serova; L. N. Shishkina; A. P. Agafonov; A. N. Sergeev

doi:10.1007/s11094-017-1629-9

Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.0^2,6.0^8,10]Dodec-11-EN-4-YL)Ureas

Autores: Selivanov B.A.¹, Tikhonov A.Y.¹, Belanov E.F.², Bormotov N.I.², Kabanov A.S.², Mazurkov O.Y.², Serova O.A.², Shishkina L.N.², Agafonov A.P.², Sergeev A.N.²
Afiliações:
1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)
2. VECTOR State Research Center of Virology and Biotechnology
Edição: Volume 51, Nº 6 (2017)
Páginas: 439-443
Seção: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244643
DOI: https://doi.org/10.1007/s11094-017-1629-9
ID: 244643

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Resumo

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.

Palavras-chave

arylisocyanates, arylisothiocyanates, 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0^2,6.0^8,10]dodec-11-en-4-yl)ureas, smallpox vaccines, antiviral activity, pharmacological activity

Sobre autores

B. Selivanov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Autor responsável pela correspondência
Email: seliboba@nioch.nsc.ru
Rússia, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090

A. Tikhonov

N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh SB RAS)

Email: seliboba@nioch.nsc.ru
Rússia, 9 Prosp. Akad. Lavrent’eva, Novosibirsk, 630090