Design of New Uracil Derivatives Possessing Inhibitory Activity with Respect to Reverse Transcriptase of HIV-1 Mutant K103N/Y181C

Resumo

New highly active N¹-substituted uracil derivatives of the HIV-1 nonnucleoside reverse transcriptase inhibitor class were designed. The structure—activity relationship provided a basis for building a computer model of the inhibitory activity against reverse transcriptase of HIV-1 mutant K103N/Y181C. New compounds that were more active than nevirapine were synthesized.