Email this article Design of New Uracil Derivatives Possessing Inhibitory Activity with Respect to Reverse Transcriptase of HIV-1 Mutant K103N/Y181C
- Authors: Pechinskii S.V.1, Kuregyan A.G.1, Ozerov A.A.2, Novikov M.S.2
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Affiliations:
- Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
- Volgograd State Medical University, MH RF
- Issue: Vol 49, No 10 (2016)
- Pages: 683-686
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244274
- DOI: https://doi.org/10.1007/s11094-016-1353-x
- ID: 244274
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Abstract
New highly active N1-substituted uracil derivatives of the HIV-1 nonnucleoside reverse transcriptase inhibitor class were designed. The structure—activity relationship provided a basis for building a computer model of the inhibitory activity against reverse transcriptase of HIV-1 mutant K103N/Y181C. New compounds that were more active than nevirapine were synthesized.
About the authors
S. V. Pechinskii
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: chem@folium.ru
Russian Federation, MH RF, Pyatigorsk, 357532
A. G. Kuregyan
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: chem@folium.ru
Russian Federation, MH RF, Pyatigorsk, 357532
A. A. Ozerov
Volgograd State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
M. S. Novikov
Volgograd State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, Volgograd, 400131
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