Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies

A. A. Litvin; R. V. Shevchenko; G. B. Kolyvanov; P. O. Bochkov; V. V. Smirnov; S. Yu. Raskin; O. G. Gribakina; V. P. Zherdev; L. G. Kolik; T. A. Gudasheva; N. Yu. Ivashkina

doi:10.1007/s11094-019-02063-3

Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies

Authors: Litvin A.A.¹, Shevchenko R.V.¹, Kolyvanov G.B.¹, Bochkov P.O.¹, Smirnov V.V.², Raskin S.Y.¹, Gribakina O.G.¹, Zherdev V.P.¹, Kolik L.G.¹, Gudasheva T.A.¹, Ivashkina N.Y.³
Affiliations:
1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
2. I. M. Sechenov First Moscow State Medical University (Sechenov University)
3. Maluna-Pharm Joint Stock Company
Issue: Vol 53, No 8 (2019)
Pages: 685-688
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245946
DOI: https://doi.org/10.1007/s11094-019-02063-3
ID: 245946

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Abstract

Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are presented. The elimination half-lives of the studied drugs are calculated in real (chronological) and corrected time (pharmacokinetic). Elimination half-lives in animals and volunteers are compared. Rabbits are found to be a better scaling model for GB-115 although a single preference for dilept was not found.

Keywords

GB-115, dilept, elimination half-life, interspecies scaling