Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies

A. A. Litvin; R. V. Shevchenko; G. B. Kolyvanov; P. O. Bochkov; V. V. Smirnov; S. Yu. Raskin; O. G. Gribakina; V. P. Zherdev; L. G. Kolik; T. A. Gudasheva; N. Yu. Ivashkina

doi:10.1007/s11094-019-02063-3

Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies

Авторлар: Litvin A.A.¹, Shevchenko R.V.¹, Kolyvanov G.B.¹, Bochkov P.O.¹, Smirnov V.V.², Raskin S.Y.¹, Gribakina O.G.¹, Zherdev V.P.¹, Kolik L.G.¹, Gudasheva T.A.¹, Ivashkina N.Y.³
Мекемелер:
1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
2. I. M. Sechenov First Moscow State Medical University (Sechenov University)
3. Maluna-Pharm Joint Stock Company
Шығарылым: Том 53, № 8 (2019)
Беттер: 685-688
Бөлім: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245946
DOI: https://doi.org/10.1007/s11094-019-02063-3
ID: 245946

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are presented. The elimination half-lives of the studied drugs are calculated in real (chronological) and corrected time (pharmacokinetic). Elimination half-lives in animals and volunteers are compared. Rabbits are found to be a better scaling model for GB-115 although a single preference for dilept was not found.