Email this article Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives
- Authors: Boiko Y.A.1, Nesterkina M.V.2,3, Shandra A.A.1, Kravchenko I.A.2,3
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Affiliations:
- Odessa National Medical University
- Odessa National Polytechnic University
- I. I. Mechnikov Odessa National University
- Issue: Vol 53, No 7 (2019)
- Pages: 650-654
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245926
- DOI: https://doi.org/10.1007/s11094-019-02056-2
- ID: 245926
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Abstract
The analgesic activity of 4-hydroxy-3-methoxybenzaldehyde (vanillin) derivatives with different pharmacophore groups were studied in vivo in models of chemically induced pain induced by subplantar administration of the TRP ion channel agonists capsaicin and allylisothiocyanate. The anti-inflammatory actions of vanillin derivatives were demonstrated in a model of carrageenan-induced edema. The analgesic and anti-inflammatory activities of vanillin and its derivatives were studied; these are linked with the effects of these substances on TRPA1 and TRPV1 receptors.
About the authors
Yu. A. Boiko
Odessa National Medical University
Email: mashaneutron@gmail.com
Ukraine, Odessa, 65000
M. V. Nesterkina
Odessa National Polytechnic University; I. I. Mechnikov Odessa National University
Author for correspondence.
Email: mashaneutron@gmail.com
Ukraine, Odessa, 65044; Odessa, 65082
A. A. Shandra
Odessa National Medical University
Email: mashaneutron@gmail.com
Ukraine, Odessa, 65000
I. A. Kravchenko
Odessa National Polytechnic University; I. I. Mechnikov Odessa National University
Email: mashaneutron@gmail.com
Ukraine, Odessa, 65044; Odessa, 65082
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