Отправить статью по E-mail Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives
- Авторы: Boiko Y.A.1, Nesterkina M.V.2,3, Shandra A.A.1, Kravchenko I.A.2,3
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Учреждения:
- Odessa National Medical University
- Odessa National Polytechnic University
- I. I. Mechnikov Odessa National University
- Выпуск: Том 53, № 7 (2019)
- Страницы: 650-654
- Раздел: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245926
- DOI: https://doi.org/10.1007/s11094-019-02056-2
- ID: 245926
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Аннотация
The analgesic activity of 4-hydroxy-3-methoxybenzaldehyde (vanillin) derivatives with different pharmacophore groups were studied in vivo in models of chemically induced pain induced by subplantar administration of the TRP ion channel agonists capsaicin and allylisothiocyanate. The anti-inflammatory actions of vanillin derivatives were demonstrated in a model of carrageenan-induced edema. The analgesic and anti-inflammatory activities of vanillin and its derivatives were studied; these are linked with the effects of these substances on TRPA1 and TRPV1 receptors.
Об авторах
Yu. Boiko
Odessa National Medical University
Email: mashaneutron@gmail.com
Украина, Odessa, 65000
M. Nesterkina
Odessa National Polytechnic University; I. I. Mechnikov Odessa National University
Автор, ответственный за переписку.
Email: mashaneutron@gmail.com
Украина, Odessa, 65044; Odessa, 65082
A. Shandra
Odessa National Medical University
Email: mashaneutron@gmail.com
Украина, Odessa, 65000
I. Kravchenko
Odessa National Polytechnic University; I. I. Mechnikov Odessa National University
Email: mashaneutron@gmail.com
Украина, Odessa, 65044; Odessa, 65082
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