Synthesis and Antimicrobial Activity of 3-Phenyl-1-Methylquinolin-2-One Derivatives

O. V. Elenich; R. Z. Lytvyn; O. V. Blinder; O. V. Skripskaya; O. S. Lyavinets; Kh. E. Pitkovych; M. D. Obushak; P. I. Yagodinets

doi:10.1007/s11094-019-01935-y

Synthesis and Antimicrobial Activity of 3-Phenyl-1-Methylquinolin-2-One Derivatives

Authors: Elenich O.V.¹, Lytvyn R.Z.², Blinder O.V.³, Skripskaya O.V.¹, Lyavinets O.S.¹, Pitkovych K.E.², Obushak M.D.², Yagodinets P.I.¹
Affiliations:
1. Yuriy Fedkovych Chernivtsi National University
2. Ivan Franko National University of Lviv
3. L. I. Medved Research Center of Preventive Toxicology, Food and Chemical Safety, Department of Medical and Environmental Problems, Ministry of Health
Issue: Vol 52, No 12 (2019)
Pages: 969-974
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245563
DOI: https://doi.org/10.1007/s11094-019-01935-y
ID: 245563

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Abstract

A series of quaternary salts were obtained by reacting 3-(4-bromoacetylphenyl)-1-methylquinolin-2(1H)-one with Py, 4-methylpyridine, quinoline, benzo[f]quinoline, and triphenylphosphine. Derivatives of thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine were produced using dinucleophilic reagents. Several of the synthesized compounds possessed high antimicrobial activity, indicating that further research on this series of compounds was promising.