电邮这篇文章 Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles
- 作者: Ishmetova R.I.1,2, Tolshchina S.G.1, Ignatenko N.K.1, Kravchenko M.A.3, Skornyakov S.N.3, Rusinov G.L.1,2, Charushin V.N.1,2
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隶属关系:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
- B. N. Yeltsin Ural Federal University
- Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
- 期: 卷 52, 编号 4 (2018)
- 页面: 304-307
- 栏目: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245148
- DOI: https://doi.org/10.1007/s11094-018-1811-8
- ID: 245148
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详细
2-Substituted 5-aryltetrazoles containing alkyl and aminoalkyl fragments were synthesized using alkylation and Mannich reactions. The tuberculostatic activity of the synthesized compounds against strain M. tuberculosis H37Rv was studied. Pronounced tuberculostatic activity (MIC ≤ 1.5 ìg/mL) was found for tetrazoles containing N(2) dimethyl- and diethylaminoethyl fragments.
作者简介
R. Ishmetova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
俄罗斯联邦, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
S. Tolshchina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
俄罗斯联邦, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
N. Ignatenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
俄罗斯联邦, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
M. Kravchenko
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
俄罗斯联邦, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
S. Skornyakov
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
俄罗斯联邦, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
G. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
俄罗斯联邦, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
V. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
俄罗斯联邦, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
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