Enviar artigo por via de e-mail Synthesis and Tuberculostatic Activity of 2-Alkyl-5-Aryltetrazoles
- Autores: Ishmetova R.I.1,2, Tolshchina S.G.1, Ignatenko N.K.1, Kravchenko M.A.3, Skornyakov S.N.3, Rusinov G.L.1,2, Charushin V.N.1,2
-
Afiliações:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
- B. N. Yeltsin Ural Federal University
- Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
- Edição: Volume 52, Nº 4 (2018)
- Páginas: 304-307
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245148
- DOI: https://doi.org/10.1007/s11094-018-1811-8
- ID: 245148
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
2-Substituted 5-aryltetrazoles containing alkyl and aminoalkyl fragments were synthesized using alkylation and Mannich reactions. The tuberculostatic activity of the synthesized compounds against strain M. tuberculosis H37Rv was studied. Pronounced tuberculostatic activity (MIC ≤ 1.5 ìg/mL) was found for tetrazoles containing N(2) dimethyl- and diethylaminoethyl fragments.
Palavras-chave
Sobre autores
R. Ishmetova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Rússia, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
S. Tolshchina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
Rússia, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
N. Ignatenko
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: chem@folium.ru
Rússia, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137
M. Kravchenko
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
S. Skornyakov
Ural Research Institute for Phthisiopulmonology, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 50 XXIInd Parts”ezda St, Ekaterinburg, 620039
G. Rusinov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Rússia, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
V. Charushin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences; B. N. Yeltsin Ural Federal University
Email: chem@folium.ru
Rússia, 22/20 S. Kovalevskoi/Akademicheskaya St, Ekaterinburg, 620137; 19 Mira St, Ekaterinburg, 620002
Arquivos suplementares
