Anisotropic Iron-Oxide Nanoparticles for Diagnostic MRI: Synthesis and Contrast Properties


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The scientific and technical literature addressing the synthesis of anisotropic iron-oxide nanoparticles of various shapes (cubic, rod-like, clustered, etc.) sized from 10 to 100 nm and their application for diagnostic magnetic resonance imaging (MRI) of tissues and organs is analyzed. The analysis indicates that the nanoparticle shape, size, and surface chemistry affect considerably relaxation parameters T1 and T2. Thus, cubic iron-oxide nanoparticles had the greatest T2 values. Furthermore, rod-like and octapodal nanoparticles also exhibit rather high T2 values so that they can be used as contrast agents for diagnostic MRI.

作者简介

A. Nikitin

National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys); Department of Chemistry, M. V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: nikitin.chemistry@mail.ru
俄罗斯联邦, 4 Leninskii Prosp., Moscow, 119991; 1/3 Leninskie Gory, GSP-1, Moscow, 119991

M. Khramtsov

National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys)

Email: nikitin.chemistry@mail.ru
俄罗斯联邦, 4 Leninskii Prosp., Moscow, 119991

A. Savchenko

National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys)

Email: nikitin.chemistry@mail.ru
俄罗斯联邦, 4 Leninskii Prosp., Moscow, 119991

M. Abakumov

National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys); N. I. Pirogov Russian National Research Medical University

Email: nikitin.chemistry@mail.ru
俄罗斯联邦, 4 Leninskii Prosp., Moscow, 119991; 1 Ostrovityanova, Moscow, 119997

A. Mazhuga

Department of Chemistry, M. V. Lomonosov Moscow State University; D. I. Mendeleev University of Chemical Technology of Russia

Email: nikitin.chemistry@mail.ru
俄罗斯联邦, 1/3 Leninskie Gory, GSP-1, Moscow, 119991; 9 Miusskaya Sq., Moscow, 125047

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