Email this article Synthesis and Pharmacological Activity of Some α-Aminoketone Hydrochlorides
- Authors: Gevorgyan G.A.1, Gasparyan N.K.1, Papoyan O.A.1, Avakimyan D.A.1, Tatevosyan A.A.1, Panosyan H.A.2
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Affiliations:
- A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- Molecular Structure Research Center, National Academy of Sciences of Armenia
- Issue: Vol 51, No 2 (2017)
- Pages: 107-110
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244512
- DOI: https://doi.org/10.1007/s11094-017-1565-8
- ID: 244512
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Abstract
New α-bromoethanones were synthesized by bromination of 1-[4(3,4)-substituted phenyl]-2-phenyl[3(4)-substituted phenyl]ethanones and were reacted with various amines in Et2O to produce the corresponding 1-[4-alkoxyphenyl(3-bromophenyl)]-2-phenyl-[3(4)-halophenyl]-2-aminoethanones. It was shown that the synthesized compounds possessed moderate antibacterial and pronounced peripheral n-cholinolytic activity.
About the authors
G. A. Gevorgyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Author for correspondence.
Email: gyulgev@gmail.com
Armenia, 26 Prosp. Azatutyan, Yerevan, 0014
N. K. Gasparyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Prosp. Azatutyan, Yerevan, 0014
O. A. Papoyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Prosp. Azatutyan, Yerevan, 0014
D. A. Avakimyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Prosp. Azatutyan, Yerevan, 0014
A. A. Tatevosyan
A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Prosp. Azatutyan, Yerevan, 0014
H. A. Panosyan
Molecular Structure Research Center, National Academy of Sciences of Armenia
Email: gyulgev@gmail.com
Armenia, 26 Prosp. Azatutyan, Yerevan, 0014
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