Formulation Development and Study of Prolonged Release from Amben Peroral Preparations Based on Hydrophobic Matrices


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Abstract

Results from research on formulation development and prolonged release of peroral 4-aminomethylbenzoic acid (amben) using hydrophobic lipid and polymer matrices are reported. It is shown that the amben release parameters considering its solubility at various pH values can be achieved by using the studied polymer hydrophobic matrices.

About the authors

G. O. Nifontova

Life Sciences Center, Moscow Institute of Physics and Technology; Farmzashchita Research and Production Center, Federal Medico-Biological Agency of the Russian Federation

Author for correspondence.
Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Oblast; Khimki, Moscow Oblast, 141402

O. V. Dolotova

Life Sciences Center, Moscow Institute of Physics and Technology

Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Oblast

I. V. Sarantseva

Life Sciences Center, Moscow Institute of Physics and Technology

Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Oblast

A. R. Akhmetzyanova

I. M. Sechenov First Moscow State Medical University

Email: galya.nif@yandex.ru
Russian Federation, Moscow, 119991

S. P. Krechetov

Life Sciences Center, Moscow Institute of Physics and Technology

Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Oblast

I. I. Krasnyuk

Farmzashchita Research and Production Center, Federal Medico-Biological Agency of the Russian Federation

Email: galya.nif@yandex.ru
Russian Federation, Khimki, Moscow Oblast, 141402

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