IgG/IgA-pemphigus — extremely rare blistering autoimmune diseases
- 作者: Karamova A.E.1, Znamenskaya L.F.1, Chikin V.V.1, Mihina V.A.1, Nefedova M.A.1
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隶属关系:
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
- 期: 卷 96, 编号 1 (2020)
- 页面: 45-51
- 栏目: CLINICAL CASE REPORTS
- URL: https://ogarev-online.ru/0042-4609/article/view/117033
- DOI: https://doi.org/10.25208/vdv554-2020-96-1-45-51
- ID: 117033
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Purpose. To present a clinical case of IgG/IgA pemphigus in a 32-year-old woman.
Material and methods. Clinical and laboratory examinations were performed to diagnose the disease: cytological examination of an impression smear from the bottom of the erosion, histological examination of a skin biopsy sample from the lesion, immunofluorescent examination of a biopsy sample of visually accessible unaffected skin.
Results. Clinical manifestations of the disease were similar to Duhring's dermatitis herpetiformis, morphological ones — to pemphigus vulgaris, but immunofluorescent examination of the skin biopsy sample in equal measure revealed deposits of both IgG and IgA in the epidermis, which allowed to determine a diagnosis of IgG/IgA pemphigus. Dapsone therapy at a dose of 100 mg per day led to a significant improvement in the patient's condition.
Conclusion. Diagnosis of bullous dermatoses requires immunofluorescent examination of a biopsy sample of visually accessible unaffected skin. Dapsone was an effective medication for the patient with IgG/IgA pemphigus.
作者简介
Arfenya Karamova
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: karamova@cnikvi.ru
Cand. Sci. (Med)., Head of the Department of Dermatology
俄罗斯联邦, Korolenko str., 3, bldg 6, Moscow, 107076Lyudmila Znamenskaya
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: karamova@cnikvi.ru
Dr. Sci. (Med.), Leading Researcher, Department of Dermatology
俄罗斯联邦, Korolenko str., 3, bldg 6, Moscow, 107076Vadim Chikin
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: karamova@cnikvi.ru
Dr. Sci. (Med.), Senior Researcher, Department of Dermatology
俄罗斯联邦, Korolenko str., 3, bldg 6, Moscow, 107076Viktoria Mihina
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: karamova@cnikvi.ru
Dermatovenerologist, Department of clinical dermatology
俄罗斯联邦, Korolenko str., 3, bldg 6, Moscow, 107076Maria Nefedova
State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation
Email: karamova@cnikvi.ru
Junior Researcher, Dermatology Department
俄罗斯联邦, Korolenko str., 3, bldg 6, Moscow, 107076参考
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