Email this article Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells
- Authors: Saburina I.N.1,2, Gorkun A.A.1, Fidarov A.F.3, Kolokol’tsova T.D.1,2, Zurina I.M.1, Kosheleva N.V.1,2, Ustinova E.E.1, Repin V.S.1
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Affiliations:
- Research Institute of General Pathology and Pathophysiology
- Biological Faculty, M. V. Lomonosov Moscow State University
- Russian Medical Academy of Postgraduate Education
- Issue: Vol 166, No 1 (2018)
- Pages: 163-169
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://ogarev-online.ru/0007-4888/article/view/240886
- DOI: https://doi.org/10.1007/s10517-018-4306-4
- ID: 240886
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Abstract
Vascularization of bioengineered bone tissue constructs remains a challenging problem of regenerative medicine. Spheroids generated in 3D culture of adipose-derived stromal cells supplemented with inducing factors demonstrate stable characteristics and express of mesenchymal, endothelial, and osteoblasts markers, and represent a prototype of vascularized microtissue. Adipose-derived stromal cells spheroids induced to both angio- and osteogenic differentiation can be used in development of new innovative technologies for in vitro fabrication of vascularized bioequivalents for repair of large bone defects.
About the authors
I. N. Saburina
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Email: kolokoltd@mail.ru
Russian Federation, Moscow; Moscow
A. A. Gorkun
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Russian Federation, Moscow
A. F. Fidarov
Russian Medical Academy of Postgraduate Education
Email: kolokoltd@mail.ru
Russian Federation, Moscow
T. D. Kolokol’tsova
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: kolokoltd@mail.ru
Russian Federation, Moscow; Moscow
I. M. Zurina
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Russian Federation, Moscow
N. V. Kosheleva
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Email: kolokoltd@mail.ru
Russian Federation, Moscow; Moscow
E. E. Ustinova
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Russian Federation, Moscow
V. S. Repin
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Russian Federation, Moscow
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