Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells
- Авторы: Saburina I.N.1,2, Gorkun A.A.1, Fidarov A.F.3, Kolokol’tsova T.D.1,2, Zurina I.M.1, Kosheleva N.V.1,2, Ustinova E.E.1, Repin V.S.1
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Учреждения:
- Research Institute of General Pathology and Pathophysiology
- Biological Faculty, M. V. Lomonosov Moscow State University
- Russian Medical Academy of Postgraduate Education
- Выпуск: Том 166, № 1 (2018)
- Страницы: 163-169
- Раздел: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://ogarev-online.ru/0007-4888/article/view/240886
- DOI: https://doi.org/10.1007/s10517-018-4306-4
- ID: 240886
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Аннотация
Vascularization of bioengineered bone tissue constructs remains a challenging problem of regenerative medicine. Spheroids generated in 3D culture of adipose-derived stromal cells supplemented with inducing factors demonstrate stable characteristics and express of mesenchymal, endothelial, and osteoblasts markers, and represent a prototype of vascularized microtissue. Adipose-derived stromal cells spheroids induced to both angio- and osteogenic differentiation can be used in development of new innovative technologies for in vitro fabrication of vascularized bioequivalents for repair of large bone defects.
Об авторах
I. Saburina
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Email: kolokoltd@mail.ru
Россия, Moscow; Moscow
A. Gorkun
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Россия, Moscow
A. Fidarov
Russian Medical Academy of Postgraduate Education
Email: kolokoltd@mail.ru
Россия, Moscow
T. Kolokol’tsova
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Автор, ответственный за переписку.
Email: kolokoltd@mail.ru
Россия, Moscow; Moscow
I. Zurina
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Россия, Moscow
N. Kosheleva
Research Institute of General Pathology and Pathophysiology; Biological Faculty, M. V. Lomonosov Moscow State University
Email: kolokoltd@mail.ru
Россия, Moscow; Moscow
E. Ustinova
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Россия, Moscow
V. Repin
Research Institute of General Pathology and Pathophysiology
Email: kolokoltd@mail.ru
Россия, Moscow
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