Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography


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Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.

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E. Rogozinskaya

Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University

Autor responsável pela correspondência
Email: elinamiss007@mail.ru
Rússia, Moscow

M. Lyapina

Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University

Email: elinamiss007@mail.ru
Rússia, Moscow

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