Email this article Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography
- Authors: Rogozinskaya E.Y.1, Lyapina M.G.1
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Affiliations:
- Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University
- Issue: Vol 164, No 2 (2017)
- Pages: 170-172
- Section: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/239450
- DOI: https://doi.org/10.1007/s10517-017-3950-4
- ID: 239450
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Abstract
Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.
About the authors
E. Ya. Rogozinskaya
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: elinamiss007@mail.ru
Russian Federation, Moscow
M. G. Lyapina
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University
Email: elinamiss007@mail.ru
Russian Federation, Moscow
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