Email this article Modulation of the Acetylcholine-Induced Input Current by Noopept in Helix Lucorum Neurons
- Authors: Murzina G.B.1, Pivovarov A.S.2
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Affiliations:
- Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
- Department of Biology, Moscow State University
- Issue: Vol 64, No 3 (2019)
- Pages: 393-399
- Section: Cell Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/152952
- DOI: https://doi.org/10.1134/S0006350919030151
- ID: 152952
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Abstract
Abstract—Possible causes of the positive modulating effect of noopept (in a concentration range of 0.1 to 10 nM) on the amplitude of the acetylcholine-induced input current are analyzed using a developed mathematical model. The results revealed that the calculated and experimental current curves coincide when the number of nicotinic acetylcholine receptors on the neuron membrane is increased or the efficiency of muscarinic acetylcholine receptors is changed.
About the authors
G. B. Murzina
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Author for correspondence.
Email: gbmurzina@mail.ru
Russian Federation, Moscow, 117485
A. S. Pivovarov
Department of Biology, Moscow State University
Email: gbmurzina@mail.ru
Russian Federation, Moscow, 119234
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