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发表评论 最可能的与靠谱系统性红斑狼疮患者皮肤活检中免疫学标志物的概述
- 作者: Lila V.A.1, Mazurov V.I.1
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隶属关系:
- North-Western State Medical University named after I.I. Mechnikov
- 期: 卷 13, 编号 1 (2021)
- 页面: 39-48
- 栏目: Original research
- URL: https://ogarev-online.ru/vszgmu/article/view/63358
- DOI: https://doi.org/10.17816/mechnikov63358
- ID: 63358
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详细
这项研究的目的是研究最可能的与靠谱系统性红斑狼疮患者的完整皮肤免疫反应谱。这项研究涉及94名患者，他们接受了标准的临床和实验室检查，并在三角肌区域进行了皮肤活检（狼疮带试验）。在靠谱系统性红斑狼疮的患者组（n=56），根据SLEDAI-2K，狼疮带试验在60.7%的病例中呈阳性，并与疾病活动相关（p=0.001）。同时，皮肤活检常显示免疫反应性IgM（85.3%），其荧光程度与双螺旋DNA抗体水平的升高直接相关（p<0.05）。在可能患有系统性红斑狼疮的检查患者中，47%的患者登记了狼疮带试验阳性，而72.2%的患者登记了IgM，这使他们更接近靠谱的系统性红斑狼疮患者组。然而，33.3%最可能的系统性红斑狼疮患者存在孤立的单一免疫反应物沉积，而靠谱系统性红斑狼疮的免疫反应（IgM + IgG）和（IgM + IgG + C3）的相关性分别为27.7例和5.5%。值得注意的是，C1q免疫反应在靠谱（38.2%）和可能的系统性红斑狼疮（39%）的皮肤活检中均检出。所获得的数据表明，具有特定免疫反应模式的狼疮带试验可作为诊断系统性红斑狼疮的一种附加试验。
作者简介
Viktoria Lila
North-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: liu_lo@mail.ru
ORCID iD: 0000-0001-5006-3358
SPIN 代码: 8348-2910
PhD student
俄罗斯联邦, 41 Kirochnaya str., Saint Petersburg, 191015Vadim Mazurov
North-Western State Medical University named after I.I. Mechnikov
Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
SPIN 代码: 6823-5482
Scopus 作者 ID: 16936315400
Researcher ID: A-8944-2016
MD, Dr. Sci. (Med.), Professor, Honoured Science Worker, Academician of the RAS
俄罗斯联邦, 41 Kirochnaya str., Saint Petersburg, 191015参考
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图1 两组患者的狼疮带试验（LBT）结果。SLE—系统性红斑狼疮
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图2 根据SLEDAI-2K（Me [25%; 75%]）数据，在靠谱系统性红斑狼疮患者中，狼疮带试验阳性[LBT(+)]和阴性[LBT(–)]组的系统性红斑狼疮活动性（n=56）
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图3 狼疮带试验阳性[LBT(+)]和阴性[LBT(–)]组中56例靠谱系统性红斑狼疮患者的dsDNA（Me [25%; 75%]）抗体滴度
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图4 靠谱系统性红斑狼疮患者（n=56）皮肤活检中免疫反应物的不同关联决定了dsDNA（Me [25%; 75%]）抗体水平
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