Dynamics of serum and placental products of cytokines, oxytocin and relaxin of women with gestational diabetes mellitus
- 作者: Krukier I.I.1, Avrutskaya V.V.1, Levkovich M.A.1, Grigoriants A.A.2, Petrov Y.A.1, Nikashina A.A.1, Chikin A.L.3
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隶属关系:
- Rostov State Medical University
- Stavropol State Medical University
- Federal Research Centre the Southern Scientifi c Centre of the Russian Academy of Sciences
- 期: 卷 75, 编号 4 (2020)
- 页面: 340-346
- 栏目: ENDOCRINOLOGY: CURRENT ISSUES
- URL: https://ogarev-online.ru/vramn/article/view/125719
- DOI: https://doi.org/10.15690/vramn1296
- ID: 125719
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Background. Pregnancy and diabetes mellitus (GDM) developed during this period are extremely unfavorable combinations for both the mother and the fetus, leading to severe consequences in the gestational period. GDM significantly increases the frequency of undesirable outcomes of pregnancy and childbirth, and also poses a serious medical and social problem for both the mother and the fetus.
Aims — to study the level of cytokines (TGFβ and IL-1β), oxytocin and relaxin in patients with gestational diabetes mellitus (GDM) in the blood serum and placenta and to show their role in the choice of delivery tactics.
Materials and methods. We examined 230 women who made up 2 groups — the control (with the physiological course of pregnancy, n = 95) and the main (with gestational diabetes, n = 135). All studies were performed in the blood serum and placenta of women of these groups. The content of TGFβ and IL-1β was determined by enzyme-linked immunosorbent assay using the R&D system (USA) and Cytimmune systems (USA) kits, and the level of relaxin and oxytocin was measured using BIOSOURCE (USA) kits.
Results. We studied the production of cytokines and relaxants in the blood serum and placenta of women with GDM is in close relationship, which is confirmed by the revealed correlation dependencies: between relaxin before birth and after they have ended (among themselves, r = 0.79; p < 0.05), as well as oxytocin (among themselves, r = 0.78; p < 0.05) in the same period. After the end of labor, a negative relationship was found in the placenta between relaxin and IL-1β (r = –0.61; p < 0.01).
Conclusions. The ratios of relaxin to oxytocin in blood serum revealed by us can be considered as possible prognostic indicators for choosing the tactics of labor management. The use of identified biochemical markers will allow timely selection of the method of delivery in women with GDM in order to reduce the risk of complications in childbirth and thereby favorably influence perinatal outcomes and reduce the incidence of newborns.
作者简介
Irina Krukier
Rostov State Medical University
编辑信件的主要联系方式.
Email: biochem@rniiap.ru
ORCID iD: 0000-0003-4570-6405
SPIN 代码: 4975-1350
Scopus 作者 ID: 56098706200
PhD in Biology, Leader Research Associate
俄罗斯联邦, 29, Nachitsevanskij, Rostov-on-Don, 344022Valeriya Avrutskaya
Rostov State Medical University
Email: v.avrutskaya@rniiap.ru
ORCID iD: 0000-0001-6399-5007
SPIN 代码: 9495-9702
MD, PhD, Associate Professor, Chief Research Associate
俄罗斯联邦, 29, Nachitsevanskij, Rostov-on-Don, 344022Marina Levkovich
Rostov State Medical University
Email: biochem@rniiap.ru
ORCID iD: 0000-0001-8047-7148
SPIN 代码: 2964-0480
MD, PhD, Associate Professor, Leader Research Associate
俄罗斯联邦, 29, Nachitsevanskij, Rostov-on-Don, 344022Armen Grigoriants
Stavropol State Medical University
Email: mr.vanhelsink@mail.ru
ORCID iD: 0000-0002-9333-2578
SPIN 代码: 6945-4464
Assistant
俄罗斯联邦, 310, Mira street, Stavropol, 355017Yuri Petrov
Rostov State Medical University
Email: mr.doktorpetrov@mail.ru
ORCID iD: 0000-0002-2348-8809
SPIN 代码: 1582-0468
MD, PhD, Professor
俄罗斯联邦, 29, Nachitsevanskij, Rostov-on-Don, 344022Anastasiya Nikashina
Rostov State Medical University
Email: Laigash@yandex.ru
ORCID iD: 0000-0001-8099-9093
SPIN 代码: 6693-3430
Scopus 作者 ID: 36696636000
PhD in Biology, Research Associate
俄罗斯联邦, 29, Nachitsevanskij, Rostov-on-Don, 344022Alexei Chikin
Federal Research Centre the Southern Scientifi c Centre of the Russian Academy of Sciences
Email: chikin@sfedu.ru
ORCID iD: 0000-0002-4065-010X
SPIN 代码: 3845-9760
PhD in Pharmaceutical Sciences, Chief Research Associate
俄罗斯联邦, 41, Chekhova ave., Rostov-on-Don, 344006参考
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