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发表评论 Vitamin D and neurospecific proteins in children with inflammatory demyelinating diseases of central nervous system
- 作者: Bukhalko M.A.1, Skripchenko E.Y.1,2, Alekseeva L.A.1, Skripchenko N.V.1,2, Monakhova N.E.1, Grigoriev S.G.1,3
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隶属关系:
- Pediatric Research and Clinical Center for Infectious Diseases
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- S.M. Kirov Military Medical Academy
- 期: 卷 10, 编号 3 (2019)
- 页面: 17-24
- 栏目: Original studies
- URL: https://ogarev-online.ru/pediatr/article/view/15676
- DOI: https://doi.org/10.17816/PED10317-24
- ID: 15676
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The relevance of studying the provision of vitamin D in children with inflammatory diseases of the central nervous system (CNS) is due to a high prevalence of vitamin D deficiency conditions in children population, which, according to current literature data, leads to the imbalance of the immune system and a predisposition to a severe disease course, chronization of the process, development of autoimmune pathology. The study of the concentration of neurospecific proteins (NSP) in blood serum and cerebrospinal fluid (CSF) has been recently used to analyze the degree and nature of nervous tissue damage in case of various CNS diseases. The study included investigation of blood serum and CSF samples obtained from 107 children (34 – with encephalitis, 28 – with disseminated encephalomyelitis (DEM), 20 – with multiple sclerosis (MS), 25 – control group). Determination of vitamin D levels (25(OH)D) was performed by the method of electrochemiluminescence immunoassay, concentrations of myelin basic protein, neuron-specific enolase, S100 protein and glial fibrillary acidic protein – by ELISA method. A decrease in the concentration of vitamin D under 30 ng/ml was found in 95% of children with inflammatory diseases of the central nervous system, while the severity of the deficiency of 25(OH)D was associated with the severity of the disease course. In the early stages of the disease in all groups, a significant increase in the level of the main myelin protein was found, while an increase in the concentration of other NSP was observed less frequently and was associated with a severe and complicated course of the disease. Correlations of different intensity and direction between NSP and 25(OH)D were found, which indicates their importance in the pathogenesis of inflammatory diseases of CNS.
作者简介
Marina Bukhalko
Pediatric Research and Clinical Center for Infectious Diseases
编辑信件的主要联系方式.
Email: marinabuhalko@mail.ru
Postgraduate Student, Department of Neuroinfections and Organic Pathology of the Nervous System
俄罗斯联邦, Saint PetersburgElena Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases; St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: wwave@yandex.ru
MD, PhD, Dr Med Sci, Senior Researcher, Department of Neuroinfections and Organic Pathology of the Nervous System; PhD, Associate Professor of the Department of Neuropsychiatry FP and DPO
俄罗斯联邦, Saint PetersburgLidiya Alekseeva
Pediatric Research and Clinical Center for Infectious Diseases
Email: kldidi@mail.ru
PhD, Leading Scientist, Department of Clinical Laboratory Diagnostics
俄罗斯联邦, Saint PetersburgNataliya Skripchenko
Pediatric Research and Clinical Center for Infectious Diseases; St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: snv@niidi.ru
MD, PhD, Dr Med Sci, Deputy Director, Department of Clinical Laboratory Diagnostics; Head of the Department of Infectious Diseases in Children FP and DPO
俄罗斯联邦, Saint PetersburgNina Monakhova
Pediatric Research and Clinical Center for Infectious Diseases
Email: kldidi@mail.ru
Researcher, Department of Clinical Laboratory Diagnostics
俄罗斯联邦, Saint PetersburgStepan Grigoriev
Pediatric Research and Clinical Center for Infectious Diseases; S.M. Kirov Military Medical Academy
Email: wwave@yandex.ru
MD, PhD, Dr Med Sci, Senior Researcher, Scientific and Organizational Department; Senior Researcher of the Research Department of the Research Center
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