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Post a Comment Clinical and functional features of the upper gastrointestinal tract in children with chronic gastroduodenitis in 3 and 6 months after eradication therapy
- Authors: Gurova M.M.1, Kupreenko V.V.2
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Affiliations:
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- Kursk State Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 10, No 2 (2019)
- Pages: 21-26
- Section: Articles
- URL: https://ogarev-online.ru/pediatr/article/view/13508
- DOI: https://doi.org/10.17816/PED10221-26
- ID: 13508
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Abstract
We studied the morphological and functional features of the stomach and duodenum in children with chronic gastroduodenitis (CGD) associated with Helicobacter pylori infection in 3 and 6 months after successful eradication therapy. Initially we carried out examination of 155 children with CGD associated with Helicobacter pylori (HP)-infection in the acute phase of the disease. In the following we examined 100 children in 3 and 6 months after the proven eradication of HP. We found that manifestations of abdominal pain syndrome was significantly decreased (100% in the acute stage versus 7% and 5% at 3 and 6 months after eradication, p < 0.01). At the same time, almost 30% of children still had symptoms of intestinal dyspepsia (31% and 36% of children after 3 and 6 months) in the form of rumbling along the colon and changes in stool. The morphological changes in the stomach and duodenum preserved in 37% of cases: was present lymphoplasmocytic infiltration of gastric mucous and atrophy in 9%. These changes were positively correlated with the identification of CagA factor. Changes in the motor-evacuation function of the stomach were characterized by disturbances in the anthro-duodenal regulation in 25% of children and positively correlated with disorders of acid-neutralizing function.
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##article.viewOnOriginalSite##About the authors
Margarita M. Gurova
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: itely@mail.ru
MD, PhD, Dr Med Sci, Leading Scientist, Laboratory “Medical and Social Problems of Pediatrics”
Russian Federation, Saint PetersburgVioletta V. Kupreenko
Kursk State Medical University, Ministry of Healthcare of the Russian Federation
Email: violettatsirkunova@mail.ru
Postgraduate Student, Department of Pediatrics
Russian Federation, KurskReferences
- Воробьева А.В. Особенности течения хронического гастродуоденита у детей (обзор литературы) // Вестник новых медицинских технологий. – 2016. – № 1. – С. 229–233. [Vorob’eva AV. The peculiarities of chronic gastroduodenitis in children (literature review). Journal of new medical technologies. 2016;(1):229-233. (In Russ.)]
- Кошимбетова Г.К. Частота встречаемости гастродуоденальной патологии у школьников // MEDICUS. – 2016. – № 2. – С. 78–79. [Koshimbetova GK. Incidence of gastro-duodenal disorder in schoolchildren. MEDICUS. 2016;(2):78-79. (In Russ.)]
- Лазарева Л.А., Гордеева Е.В. Анализ заболеваемости детей и подростков болезнями органов пищеварения // Международный Исследовательский журнал. – 2017. – № 1-1. – С. 133–135. [Lazareva LA, Gordeeva EV. Analysis of digestive apparatus disease incidence among children and adolescents. Mezhdunarodnyy Issledovatel’skiy zhurnal. 2017;(1-1):133-135. (In Russ.)]
- Листопадова А.П., Аничков Н.М., Петровский А.Н., и др. Морфологические особенности слизистой оболочки желудка у детей с ювенильным артритом // Экспериментальная и клиническая гастроэнтерология. – 2014. – № 6. – С. 8–12. [Listopadova AP, Anichkov NM, Petrovskiy AN, et al, Morphological features of the gastric mucosa in children with juvenile arthritis and chronic gastritis. Eksp Klin Gastroenterol. 2014;(6):8-12. (In Russ.)]
- Новикова В.П., Сатар Абдул Ш., Юрьев В.В., и др. Хеликобактериоз и персистирующие инфекции при аутоимунном хроническом гастрите у детей // Детская гастроэнтерология. – 2006. – № 4. – С. 12–16. [Novikova VP, Satar Abdul Sh, Yur’ev VV, et al. Khelikobakterioz i persistiruyushchie infektsii pri autoimunnom khronicheskom gastrite u detey. Detskaya gastroenterologiya. 2006;(4):12-16. (In Russ.)]
- Новикова В.П., Цех О.М., Рудиченко А.Н., Калинина Е.Ю. Морфо-функциональные особенности слизистой оболочки двенадцатиперстной кишки при хроническом гастродуодените у пациентов разного возраста // Российский журнал гастроэнтерологии, гепатологии, проктологии. - 2008, 5. - С.51. [Novikova VP, Tsekh OM, Rudichenko AN, Kalinina EY. Morfo-funktsional’nye osobennosti slizistoy obolochki dvenadtsatiperstnoy kishki pri khronicheskom gastroduodenite u patsientov raznogo vozrasta. Rossiyskiy zhurnal gastroenterologii, gepatologii, proktologii. 2008(5):51. (In Russ.)]
- Fock KM. Functional dyspepsia, H. pylori and post infectious FD. J Gastroenterol Hepatol. 2011;26 Suppl 3:39-41. https://doi.org/10.1111/j.1440-1746.2011.06649.x.
- gastroscan.ru [интернет]. Indrio F, Riezzo G, Raimondi F, и др. Влияние пробиотиков на опорожнение желудка у младенцев [доступ от 09.05.2019]. Доступ по ссылке http://www.gastroscan.ru/literature/authors/5660 [gastroscan.ru [Internet]. Indrio F, Riezzo G, Raimondi F, et al. Vliyanie probiotikov na oporozhnenie zheludka u mladentsev [cited 2019 May 09]. Available from: http://www.gastroscan.ru/literature/authors/5660. (In Russ.)]
- Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130(5): 1466-79. https://doi.org/10.1053/j.gastro.2005.11.059.
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