The role of endothelium in hemostasis mechanisms

Formation and excretion of thrombogenous and athrombogenous factors by endothelial cells is a constant physiological process taking place in all vessels. Endothelium is a huge endocrine gland which generates a wide spectrum of biologically active substances. Biologically active substances of endothelium are involved in many hemostasis mechanisms and regulation of local blood flow. BAS composition is determined by status of endothelial cells. In physiological state BAS of endothelium provide adequate local blood flow by synthesizing powerful anticoagulants, vasodilators and other biologically active substances. Activity of endothelium in physiological conditions provides trophism of tissues and fulfils protective function. Disturbance of any function or structure of endothelium significantly changes the spectrum of biologically active substances. Endothelium starts to secrete aggregants, coagulants, vasoconstrictors and other factors many of which contribute to generalization of the pathological process.

inhibitors of plasminogen activators, tissue factor inhibitor, nitric oxide, prostacyclin, tissue and urokinase plasminogen activators, thrombomodulin, von Willebrand factor, endothelial cells