电邮这篇文章 THE VALUE OF MICROBIOLOGICAL MONITORING AND DETERMINING THE MOLECULAR GENETIC CHARACTERISTICS OF HOSPITAL MICROFLORA OF PURULENT OSTEOLOGY DEPARTMENT
- 期: 卷 24, 编号 3 (2016)
- 页面: 44-52
- 栏目: Articles
- URL: https://ogarev-online.ru/pavlovj/article/view/4529
- DOI: https://doi.org/10.17816/PAVLOVJ2016344-52
- ID: 4529
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434 microbial strains found in Purulent Osteology Department patients were analyzed. 203 infectious agents were found in patients with purulence after major joint prosthetics, 148 - in patients with chronic osteomyelitis, 83 - in diabetic foot patients. Grampositive microorganisms accounted for 302 strains, gram-negative ones - for 132 strains. Irrespective of nosology, main infectious agents were represented by various staphylococci, a third of which expressed mec A gene displaying a phenotype of methicillin-resistant strains. Ps. Aeruginosa was second in detection rate, among which 9 strains out of 51 had a gene encoding VIM-type Metallo-beta-lactamase production. The third place in detection rate belonged to A. baumanii. 15 strains producing OХА-40-like carbapenemases were found among 29 acinetobacter isolates. 14 out of 19 K. pneumoniae strains produced extended spectrum beta-lactamases. Therefore, similar patterns in infectious agent structure were found in Purulent Osteology Department patients with various infectious processes: staphylococci predominance and circulation of a great number of antibiotic multiresistant microorganisms. A thorough microbiological monitoring enables determining of phenotype and genotype of antibiotic resistance and prescribing a balanced antimicrobic therapy.
参考
- Алексеев Д.Г. Комплексное лечение хронического остеомиелита с применением рациональной антиинфекционной химиотерапии и иммунокоррекции: автореф. дис.. канд. мед. наук. Самара, 2006. 36 с.
- Божкова С.А., Тихилов Р.М., Краснова М.В., Рукина А.Н., Тишина В.В., Полякова Е.М. Профиль резистентности возбудителей как основа выбора 2 эффективного антибиотика при стафилококковых инфекциях протезированных суставов // Клиническая микробиология и антимикробная химиотерапия. 2013. Т. 15, № 2. С. 115-120.
- Теплякова О.В., Руднов В.А., Шлыкова Г.И., Доценко Т.Г. Септический артрит у взрослых // Клиническая микробиология и антимикробная химиотерапия. 2015. Т. 17, № 3. С. 187-206.
- Slater R., Lazarovitch I., Boldur I.Swab cultures accurate ly identify bacterial pathogens in diabetic foot wounds not involving bone // Diabet Med. 2004. Vol. 21. P. 705-709.
- Ong K.L., Kurtz S.M., Lau E., Bozic K.J., Berry D.J., Parvizi J. Prosthetic joint infection risk after total hip arthroplasty in the medicare population //J. Artrhroplasty. 2009. Vol. 24 (6 Suppl.). S105-109.
- Гостев В.В., Гончаров А.Е., Грачева М.А., Сидоренко С.В. Распространение генов комплекса Immune evasion claster и других факторов вирулентности у Staphylococcus aureus // Клиническая микробиология и антимикробная химиотерапия. 2013. Т. 15, №4. С. 270-279.
- Lie S.A., Havelin L.I., Furnes O.N., Engesaeter L.B., Vollset S.E. Failure rates for 4762 revision total hip arthroplasties in the Norwegian Arthroplasties Register // J.Bone Jt. Surg. 2004. Vol. 86-B, №4. P. 504-509.
- Методические указания МУК 4.2.1890-04 «Определение чувствительности микроорганизмов к антибактериальным препаратам». М., 2004.
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