Analysis of In-Hospital Mortality of Patients with New Coronavirus Infection (COVID-19) of Clinical Centre of Sechenov University

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Abstract

INTRODUCTION: The epidemic of a new coronavirus infection (COVID-19) required a restructure of the entire healthcare system of the Russian Federation within a limited period of time. Here, the mortality of patients is the most important effective parameter that reflects successfulness of organization measures for improvement of the activity of medical institutions. The initial preparedness of the infrastructure permitted to rapidly deploy a hospital on the base of the Clinical Centre of Sechenov University for providing medical assistance to patients with COVID-19.

AIM: To analyze the in-hospital mortality of patients with COVID-19 at the Clinical Center of Sechenov University.

MATERIALS AND METHODS: The COVID-19 database (n = 19 230) of the Clinical Centre of Sechenov University for 2020–2022 was analyzed.

RESULTS: The overall in-hospital mortality in COVID-19 hospitals of the Clinical Centre of Sechenov University was 8.5%, which is the lower level compared to the data of foreign studies (Italy, Spain, Great Britain, USA, Iran). The main predictors of mortality are: basic — male gender, age (mainly > 75 years); existence of malignant neoplasms, diseases of the nervous system, diseases of the cardiovascular system, diseases of the endocrine system in patients; diseases occurring in the course of hospital treatment — artificial lung ventilation, past surgical interventions.

CONCLUSION: The working experience of the Clinical Center of Sechenov University shows a possibility for quick salvation of organizational tasks facing the healthcare system in the period of COVID-19 pandemic, with the results characterized by low lethality of hospitalized patients.

About the authors

Viktor V. Fomin

I. M. Sechenov First Moscow State Medical University (Sechenov University)

Email: fomin_v_v_1@staff.sechenov.ru
ORCID iD: 0000-0002-2682-4417
SPIN-code: 8465-2747

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Valeriy V. Royuk

I. M. Sechenov First Moscow State Medical University (Sechenov University)

Email: vvroyuk@mail.ru
ORCID iD: 0000-0002-4966-3767
SPIN-code: 7535-4008

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Moscow

Vladimir A. Reshetnikov

I. M. Sechenov First Moscow State Medical University (Sechenov University)

Email: resh1960@mail.ru
ORCID iD: 0000-0002-7853-7356
SPIN-code: 4016-2059

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Ol’ga S. Volkova

I. M. Sechenov First Moscow State Medical University (Sechenov University)

Email: volkova_o_s@staff.sechenov.ru
ORCID iD: 0000-0002-4568-1298
SPIN-code: 1758-1266

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Natan G. Korshever

Saratov State Medical University named after V. I. Razumovsky

Email: korshever@bk.ru
ORCID iD: 0000-0002-5545-6844
SPIN-code: 3665-2116

MD, Dr. Sci. (Med.), Professor

Russian Federation, Saratov

Vasiliy V. Kozlov

Azerbaijan Medical University

Author for correspondence.
Email: kvv.doc@gmfil.com
ORCID iD: 0000-0002-2389-3820
SPIN-code: 7703-0013

MD, Cand. Sci. (Med.), Associate Professor

Azerbaijan, Baku

References

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2. Fig. 1. Mortality rate of patients with a new coronavirus infection (COVID-19) depending on age at the Clinical Center of Sechenov University in 2020–2022, р ˂ 0.001

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3. Fig. 2. ROC-curve of the fatal outcome predictor model of patients with COVID-19 at the Clinical Center of Sechenov University in 2020–2022

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