The effect of changes in retinal perfusion on postoperative recovery of foveal function in full-thickness macular holes
- 作者: Boiko E.V.1,2, Doktorova T.A.1, Suetov A.A.1,3, Sosnovskii S.V.1
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隶属关系:
- S. Fyodorov Eye Microsurgery Federal State Institution
- North-Western State Medical University named after I.I. Mechnikov
- State Scientific Research Test Institute of Military Medicine
- 期: 卷 18, 编号 1 (2025)
- 页面: 7-16
- 栏目: Original study articles
- URL: https://ogarev-online.ru/ov/article/view/312588
- DOI: https://doi.org/10.17816/OV634854
- ID: 312588
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详细
BACKGROUND: Data on the effect of changes in retinal perfusion on retinal functional recovery at surgical treatment of full-thickness macular holes are limited.
AIM: To investigate the effect of changes in retinal perfusion on postoperative recovery of fovea function in full-thickness macular holes.
MATERIALS AND METHODS: A prospective study included data of 93 patients (93 eyes) with full-thickness macular holes. Optical coherence tomography-angiography (OCT-A), visual acuity testing, microperimetry, and multifocal electroretinography were performed before surgical treatment, after 1 and 6 months. We studied the relationship between changes in foveal avascular zone area, vessel density in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) with changes in best corrected visual acuity (BCVA), retinal sensitivity (RS) at the fixation point and P1 amplitude in the fovea at different periods after treatment.
RESULTS: After surgical hole closure, a significant decrease in foveal avascular zone area, increase in vascular density in SCP and DCP was found within 1 month after treatment (p < 0.001). Significant increase in BCVA, RS and P1 amplitude was observed 1 and 6 months after hole closure (p < 0.001). The most pronounced correlation was found in the long-term postoperative period between the change in vessel density in the SCP and the change in BCVA, RS and P1 amplitude (r = 0.42, r = 0.26 and r = 0.3, p < 0.05), as well as between the change in vessel density in the DCP and the change in BCVA, RS and P1 amplitude (r = 0.41, r = 0.34 and r = 0.43, p < 0.05).
CONCLUSIONS: In the treatment of patients with full-thickness macular holes, there is a significant relationship between changes in retinal perfusion and the recovery of visual acuity, retinal sensitivity and bioelectrical activity in the foveal area, and it is more pronounced in the period from 1 to 6 months after macular hole closure. The obtained results suggest a possible prognostic role of OCTA results in the surgical treatment of full-thickness macular holes.
作者简介
Ernest Boiko
S. Fyodorov Eye Microsurgery Federal State Institution; North-Western State Medical University named after I.I. Mechnikov
Email: boiko111@list.ru
ORCID iD: 0000-0002-7413-7478
SPIN 代码: 7589-2512
MD, Dr. Sci. (Medicine), Professor, Honored Doctor of the Russian Federation
俄罗斯联邦, 21 Yaroslava Gasheka st., Saint Petersburg, 192283; Saint PetersburgTaisiia Doktorova
S. Fyodorov Eye Microsurgery Federal State Institution
Email: taisiiadok@mail.ru
ORCID iD: 0000-0003-2162-4018
SPIN 代码: 8921-9738
MD
俄罗斯联邦, 21 Yaroslava Gasheka st., Saint Petersburg, 192283Alexey Suetov
S. Fyodorov Eye Microsurgery Federal State Institution; State Scientific Research Test Institute of Military Medicine
编辑信件的主要联系方式.
Email: ophtalm@mail.ru
ORCID iD: 0000-0002-8670-2964
SPIN 代码: 4286-6100
MD, Cand. Sci. (Medicine)
俄罗斯联邦, 21 Yaroslava Gasheka st., Saint Petersburg, 192283; Saint PetersburgSergey Sosnovskii
S. Fyodorov Eye Microsurgery Federal State Institution
Email: svsosnovsky@mail.ru
ORCID iD: 0000-0002-1745-5146
SPIN 代码: 3058-7913
MD, Cand. Sci. (Medicine); Assistant Professor
俄罗斯联邦, 21 Yaroslava Gasheka st., Saint Petersburg, 192283参考
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