Pulmonary hypertension and respiratory function in parenchyma sparing surgical treatment of lung cancer
- Authors: Kirshin AA1,2, Napol'skikh VM2
-
Affiliations:
- Republican Clinical Oncological Dispensary n.a. S.G. Primushko
- Izhevsk State Medical Academy, department of oncology
- Issue: Vol 99, No 6 (2018)
- Pages: 876-879
- Section: Theoretical and clinical medicine
- URL: https://ogarev-online.ru/kazanmedj/article/view/10499
- DOI: https://doi.org/10.17816/KMJ2018-876
- ID: 10499
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Abstract
Aim. To assess the effect of pulmonary hypertension on respiratory function in lung cancer surgery.
Methods. 92 patients diagnosed with non-small cell lung cancer, among them 69 men (75 %) and 23 women (25 %), were operated on with different variants of angioplastic lobectomy (APL), the average age was 57.8 ± 6.7 years. 91 patients underwent pulmonectomy (PE), among them 87 men (95.6 %) and 4 women (4.4 %), the average age was 59 ± 8.8 years.
Results. One year after angioplastic lobectomy FEV1 decreased by 0.69 liters (27 %), vital capacity decreased by 1.17 liters (32.9 %), FVC (the difference between the volumes of lungs at the beginning and at the end of forced expiration) reduced by 0.64 liters (20.5 %). After removal of the lung, dynamics of the decrease of similar indicators was 1.02 (42 %); 1.53 (43.8 %); 1.24 (40.3 %) liter respectively. The presence of a negative relationship between PA/A (pulmonary artery/aorta) and FEV1 was revealed. Thus, in the group of angioplastic lobectomy without initial pulmonary hypertension (PA/A less than 1) it was found that r = -0.42 (p < 0.01), with pulmonary hypertension (PA/A 1 or more) r = -0.4 (p < 0.01). In the group of pulmonectomy without initial pulmonary hypertension, the correlation index was -0.38 (p < 0.01), with initial pulmonary hypertension r = -0.33 (p < 0.01).
Conclusion. The analysis of the functional parameters of pulmonary system after the surgery revealed statistically significant advantage of organ-saving treatment, as well as negative correlation between pulmonary hypertension and respiratory function.
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##article.viewOnOriginalSite##About the authors
A A Kirshin
Republican Clinical Oncological Dispensary n.a. S.G. Primushko; Izhevsk State Medical Academy, department of oncology
Author for correspondence.
Email: kirshinalex80@mail.ru
Izhevsk, Russia
V M Napol'skikh
Izhevsk State Medical Academy, department of oncology
Email: kirshinalex80@mail.ru
Izhevsk, Russia
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