On the nature and mechanisms of functional activity disorder of hepatic macrophages after extreme action on organism

Abstract

The dynamics of morphofunctional state disorders of stellate reticuloendotheliocytes of the liver is studied using models of traumatic and burn shock in rats. The course of shock process is accompanied by progressive supression of the phagocytic function of RES and destructive changes of hepatic macrophages. An intimate connection between the disfunction of RES of the liver, intraorgan blood flow disorder, plasma fibronectine concentration change and hemocoagulative disorders U revealed. The important role of the functional activity of mononuclear phagacytes system in shock pathogenesis is supported in experiments with artificial stimulation and blockade of RES.

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