Results of hemosorption in pneumonia

In recent years, there has been a clear trend towards a prolonged course of acute pneumonia with subsequent chronization of the process. The causes of unfavorable outcomes of the disease are the late treatment of patients for medical care, irrational treatment and inadequate reaction of the body to the introduction of infectious agents. The latter can be genetically determined or caused by the action of environmental factors, including microbes. As previously conducted observations [1] have shown, an unfavorable course of acute pneumonia is observed in patients with insufficient anti-infection protection response. We found that an undesirable course of the disease is detected if phagocytosis and immune response to microbial antigens are not activated by the 7th-10th day. On this basis, it was concluded that the outcome of pneumonia depends more on the response of the macroorganism to the infectious agent and is less associated with antimicrobial therapy. Taking into account these data and the results of the study by V. P. Silvestrov and N. F. Vanina (1980), we concluded that, along with antimicrobial therapy, stimulation of anti-infective protection is necessary. Our attention was attracted by hemosorption proposed by Y. M. Lopukhin and M. N. Molodenkov (1978). As studies conducted to date have shown, extracorporeal detoxification helps to remove toxic compounds and microbes from the body. This possibility has been established during clinical observations in patients with sepsis [2-4, 8, 10, 11, 13]. In addition, in the work of M. N. Molodenkov et al. (1981) it was shown that hemosorption can stimulate the activity of anti-infective protection. It was also used for bronchial asthma [121 and chronic suppurative processes in the lungs [6].