Clinical manifestations of impaired function of the apud system

L. I. Anchikova; Анчикова Л. И.; L. N. Kurshakova; Куршакова Л. Н.; V. P. Maslov; Маслов В. П.; R. I. Khamidullin; Хамидуллин Р. И.; K. S. Zakirzyanov; Закирзянов К. Ш.

doi:10.17816/kazmj86537

Clinical manifestations of impaired function of the apud system

Authors: Anchikova L.I.¹^,2^,3, Kurshakova L.N.¹^,2^,3, Maslov V.P.¹^,2^,3, Khamidullin R.I.¹^,2^,3, Zakirzyanov K.S.¹^,2^,3
Affiliations:
1. Kazan Institute for Advanced Training of Doctors named after V.I. V.I. Lenin
2. Kazan Department Hospital No. 2
3. Ministry of Railways of the USSR
Issue: Vol 64, No 6 (1983)
Pages: 441-444
Section: Lectures
URL: https://ogarev-online.ru/kazanmedj/article/view/86537
DOI: https://doi.org/10.17816/kazmj86537
ID: 86537

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Abstract

In the human body, there is a neuroendocrine cell system, the main functional feature of which is the ability of cells to form biogenic amines and polypeptide hormones. The name "APUD-system" is made up of the initial letters of the main general properties of the cells included in this system [7]. Cells of the APUD-system (apudocytes) are found in the pituitary gland, hypothalamus, pineal gland, in the organs of the gastrointestinal tract, genitourinary system, respiration, in the heart, endocrine glands, etc. Apudocytes produce serotonin, melatonin, catecholamines, histamine, gastrin, glucagon , liberins and statins of the hypothalamus, etc. Overproduction or lack of certain hormones and biogenic amines due to disturbances in the structure and function of cells of the APUD-system lead to dysfunction of the system as a whole, which is expressed in a particular clinical syndrome. - apudopathy. I. M. Kvetnoy and H. T. Raikhlin (1978) proposed a working classification of apudopathies.

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