Immunologic investigations of perilymph in patients with otosclerosis

Abstract

The investigation of the dynamics of the content of IgA, IgM, IgG and antibodies to DNA in blood serum and perilymph of 30 patients with otosclerosis, in 20-th active stage and in 10-th nonactive one, shows the plausible increase of the levels of IgG and antobodies to DNT, more pronounced in the active stage of the disease relative to the nonactive stage. The inverse correlation between immunologic characteristics and ear levels is found: namely, the decrease of IgG levels and antibodies to DNA in perilymph of patients with otosclerosis and hence, the decrease of the process activity is accompanied by the auditory function suppression in the form of the increase of perception theresholds of osteoconductive sounds on vocal and high rates.

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