The content of estrogenic hormones in tissues and urine with uterine fibroids

The amount of estrogenic hormones in the urine and tissues of the endometrium, myometrium and myomatous nodes in 10 patients with uterine myoma before surgery during the menstrual cycle, as well as in urine and in the tissues of the uterus after its surgical removal was investigated. It was found that there is no difference in the content of estrogens in the myometrium and myomatous nodes. This means that myomatous nodes do not show an increased ability to accumulate hormones in comparison with neighboring unchanged muscle tissue. The obtained weak correlation dependence of estrogen hormones excreted in the urine and contained in the tissues of the uterus does not give the right to draw conclusions about changes in the hormonal balance in the tissues of the uterus only by determining the amount of estrogen in the urine. All the more difficult it is only on the basis of studying the excretion of estrogenic hormones in the urine to judge their significance in the occurrence of uterine fibroids.