Epidemiological surveillance of surgical site infections in large joint replacement

Cover Page

Cite item

Abstract

Joint replacement is a reliable and effective surgery that allows profound pain relief and restores joint function in patients. Despite the progress made and the experience gained in joint replacement, surgical site infection is one of the leading postoperative complications. It can proceed as a periprosthetic joint infection, osteomyelitis, sepsis and lead to disabled or dead outcomes. Systematization of risk factors for infectious complications plays an important role as an element of epidemiological surveillance system optimization. Age, the presence of concomitant diseases (for example, diabetes mellitus, cancer, arthritis and systemic collagenosis), carriage of antimicrobial-resistant microorganisms, infectious and inflammation both outside and in the area of surgery, and external factors (surgery duration, correct antibiotic prophylaxis and surgeon's experience) are the most significant risk factors for periprosthetic joint infection. In world practice, the National Nosocomial Infections Surveillance System surgical site infection risk index is used. This criterion does not consider all potential risk factors. It is important to analyze and rank the identified risk factors according to the impact on the development of infectious complications in organizing an epidemiological surveillance system process in a medical organization. Risk factors analysis will identify the most significant modifiable factors for the development, implementation and execution of organizational, preventive measures and epidemic control. The creation and implementation of a standardized preoperative protocol based on a risk factors assessment will allow predicting the surgery outcome and arguing the strategy and tactic of preventive measures.

About the authors

Irina A. Bulycheva

Kazan State Medical University; City Polyclinic No. 21

Author for correspondence.
Email: Irishe4ka_94@mail.ru
ORCID iD: 0000-0001-7289-3037
SPIN-code: 5183-5140

Assistant, Depart. of Epidemiology and Evidence-based Medicine; Epidemiologist, Kazan Outpatient Clinic No. 21

Russian Federation, Kazan, Russia; Kazan, Russia;

Ksenija A. Kondratieva

Kazan State Medical University

Email: kseenia97@mail.ru
ORCID iD: 0000-0002-3004-0412

Resident, Depart. of Hospital Pediatrics

Russian Federation, Kazan, Russia

Gulnara R. Yakupova

Kazan State Medical University

Email: gulnarochka_97@mail.ru
ORCID iD: 0000-0003-2217-7352

Resident, Depart. of Preventive Medicine

Russian Federation, Kazan, Russia

Alla I. Lokotkova

Kazan State Medical University

Email: Allalok12@mail.ru
ORCID iD: 0000-0003-4482-6050
SPIN-code: 5262-1969

Cand. Sci. (Med.), Assoc. Prof., Depart. of Epidemiology and Evidence-based Medicine

Russian Federation, Kazan, Russia

Eldar Kh. Mamkeev

Kazan State Medical Academy — Branch Campus of Russian Medical Academy of Continuous Professional Education

Email: mamkeevv@mail.ru
ORCID iD: 0000-0002-3781-8629

Cand. Sci. (Med.), Assoc. Prof., Depart. of Epidemiology and Disinfectology

Russian Federation, Kazan, Russia

Marat R. Mazitov

Kazan State Medical University; City Polyclinic No. 21

Email: marat.mazitov@tatar.ru
ORCID iD: 0000-0002-2462-3005

Assistant, Depart. of General Hygiene; Deputy Chief Physician for Medical Affairs

Russian Federation, Kazan, Russia; Kazan, Russia

References

  1. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg. 2007;89(4):780–785. doi: 10.2106/JBJS.F.00222.
  2. Vorokov AA, Bortulev PI, Khaydarov VM, Linnik SA, Tka­chenko AN. Total hip and knee arthoplasty: on the issue of indications for surgery. Pediatric Orthopedics, Traumatology and Reconstructive Surgery. 2020;8(3):355–364. (In Russ.) doi: 10.17816/PTORS34164.
  3. Anyaehie UE, Muoghalu ON, Onuminya JE. Periprosthetic joint infection: The unending journey. Niger J Orthop Trauma. 2020;19:10–18. doi: 10.4103/njot.njot_6_20.
  4. Slobodskoy AB, Osintsev EYu, Lezhnev AG, Voronin IV, Badak IS, Dunaev AG. Risk factors for periprosthetic infection after large joint arthroplasty. NN Priorov Journal of Traumatology and Orthopedics. 2015;22(2):13–18. (In Russ.) doi: 10.17816/vto201522213-18.
  5. Barrett L, Atkins B. The clinical presentation of prosthetic joint infection. J Antimicrob Chemother. 2014;69(1):i25–i27. doi: 10.1093/jac/dku250.
  6. Wu C, Qu X, Liu F, Li H, Mao Y, Zhu Z. Risk factors for periprosthetic joint infection after total hip arthroplasty and total knee arthroplasty in Chinese patients. PLoS One. 2014;9(4):e95300. doi: 10.1371/journal.pone.0095300.
  7. Lentino JR. Prosthetic joint infections: Bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis. 2003;36(9):1157–1161. doi: 10.1086/374554.
  8. Prokhorenko VM, Slobodskoy AB, Mamedov AA, Dunaev AG, Voronin IV, Badak IS, Lezhnev AG. Compa­rative analysis of short and mid-term results of primary total hip replacement by serial cemented and uncemented fi­xation implants. NN Priorov Journal of Traumatology and Orthopedics. 2014;21(3):21–26. (In Russ.) doi: 10.17816/vto20140321-26.
  9. Mühlhofer HML, Feihl S, Suren C, Banke IGJ, Pohlig F. Implant-associated joint infections. Orthopade. 2020;49(3):277–286. (In Germ.) doi: 10.1007/s00132-020-03877-w.
  10. Whitehouse JD, Friedman ND, Kirkland KB, Ri­chardson WJ, Sexton DJ. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol. 2002;23(4):183–189. doi: 10.1086/502033.
  11. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2019 godu. Gosudarstvennyy doklad. (The state of sanitary and epidemiological well-being of the population in the Russian Federation in 2019. State report.) Moscow: Federal'naya sluzhba po nad­zoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka; 2020. 300 p. (In Russ.)
  12. O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiyskoy Federatsii v 2016 godu. Gosudarstvennyy doklad. (The state of sanitary and epidemiological well-being of the population in the Russian Federation in 2016. State report.) Moscow: Federal'naya sluzhba po nad­zoru v sfere zashchity prav potrebiteley i blagopoluchiya cheloveka; 2017. 220 p. (In Russ.)
  13. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992;13(10):606–608. doi: 10.1016/s0196-6553(05)80201-9.
  14. Patient Safety Component Manual 2021: U.S. National Healthcare Safety Network (NHSN). Centers for Disease Control and Prevention. https://www.cdc.gov/nhsn/pdfs/pscmanual/pcsmanual_current.pdf (access date: 28.03.2021).
  15. Cherkassky BL. The concept “risk” in epidemiology. Epidemiologiya i infektsionnye bolezni. 2006;4:5–10. (In Russ.)
  16. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control. 1999;27(2):97–132. doi: 10.1016/S0196-6553(99)70088-X.
  17. Brusina EB, Kova­lishena OV, Tsigelnik AM. Healthcare-associated infections: Trends and prevention prospectives. Epidemiology and Vaccinal Prevention. 2017;16(4):73–80. (In Russ.) doi: 10.31631/2073-3046-2017-16-4-73-80.
  18. Epidemiologicheskoe nablyudenie za infektsiyami, svyazannymi s okazaniem meditsinskoy pomo­shchi. Fe­deral'nye klinicheskie rekomendatsii. (Epidemiological surveillance of healthcare associated infections. Federal clinical guidelines.) Moscow: Natsional'naya assotsiatsiya spetsialistov po kontrolyu infektsiy, svyazannykh s okazaniem meditsinskoy pomoshchi; 2014. 58 p. (In Russ.)
  19. Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Ilstrup DM, Harmsen WS, Osmon DR. Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis. 1998;27(5):1247–1254. doi: 10.1086/514991.
  20. Namba RS, Inacio MCS, Paxton EW. Risk factors associated with deep surgical site infections after primary total knee arthroplasty: an analysis of 56,216 knees. J Bone Joint Surg Am. 2013;95(9):775–782. doi: 10.2106/JBJS.L.00211.
  21. Programma SKAT (Strategija Kontrolja Antimikrobnoj Terapii) pri okazanii stacionarnoj medicinskoj pomoshhi. Rossijskie klinicheskie rekomendacii. (Antimicrobial Therapy Control Strategy for inpatient care. Russian clinical guidelines.) Moscow: Pero; 2018. 79 p. (In Russ.)
  22. Janz V, Löchel J, Trampuz A, Schaser KD, Hofer A, Wassilew GI. Risk factors and management strategies for early and late infections following reconstruction with special tumour endoprostheses. Orthopade. 2020;49(2):142–148. doi: 10.1007/s00132-020-03872-1.
  23. Jämsen E, Nevalainen P, Eskelinen A, Huotari K, Kalliovalkama J, Moilanen T. Obesity, diabetes, and preope­rative hyperglycemia as predictors of periprosthetic joint infection: A single-center analysis of 7181 primary hip and knee replacements for osteoarthritis. J Bone Joint Surg. 2012;94(14):e101. doi: 10.2106/JBJS.J.01935.
  24. Abdulla I, Mahdavi S, Khong H, Gill R, Powell J, Johnston DK, Sharma R. Does body mass index affect the rate of adverse outcomes in total hip and knee arthroplasty? A retrospective review of a total joint replacement database. Can J Surg. 2020;63(2):E142–E149. doi: 10.1503/cjs.006719.
  25. Alvi HM, Mednick RE, Krishnan V, Kwasny MJ, Beal MD, Manning DW. The effect of BMI on 30 day outcomes following total joint arthroplasty. J Arthroplasty. 2015;30:1113–1117. doi: 10.1016/j.arth.2015.01.049.
  26. Somayaji R, Barnabe C, Martin L. Risk factors for infection following total joint arthroplasty in rheumatoid arthritis. Open Rheumatol J. 2013;7(1):119–124. doi: 10.2174/1874312920131210005.
  27. Zubritsky VF, Koz­lov YuA. Infectious complications during large joint replacement. Vestnik Natsional'nogo mediko-khirurgicheskogo Tsentra imeni NI Pirogova. 2012;7(1):98–103. (In Russ.)
  28. Khramov AE, Makarov MA, Byalik EI, Makarov SA, Belov BS, Pavlov VP, Rybnikov AV, Amirdzhanova VN. Periprosthetic joint infection in patients with rheumatic diseases: the problems of diagnosis, prevention, and treatment. Rheumatology ­Science and Practice. 2015;53(5):558–563. (In Russ.) doi: 10.14412/1995-4484-2015-558-563.
  29. Belov BS, Makarov SA, Byalik EI. Bacterial (septic) arthritis and prosthetic joint infection. Rheumatology Science and Practice. 2017;55(2):192–200. (In Russ.) doi: 10.14412/1995-4484-2017-192-200.
  30. Antonelli B, Chen AF. Reducing the risk of infection after total joint arthroplasty: preoperative optimization. Arthroplasty. 2019;1(1):4. doi: 10.1186/s42836-019-0003-7.
  31. Вorisova LV, Nikolaev NS, Preobrazhenskaya EV, Pchelova NN, Didichenko SN. Causes of infectious complications after hip arthroplasty and measures to reduce them. Kafedra travmatologii i ortopedii. 2018;(2):9–13. (In Russ.) doi: 10.17238/issn2226-2016.2018.2.9-13.
  32. Nikolaev NS, Borisova LV, Pchelova NN, Orlova AV, Karalin AN. Practical recommendations concerning diagnostics of implant-associated infection in the course of endoprosthetics of large joints under modern conditions. Me­dical Almanac. 2016;(3):40–45. (In Russ.)
  33. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet. 2001;358(9276):135–138. doi: 10.1016/s0140-6736(01)05321-1.
  34. Scheuermann-Poley C, Wagner C, Hoffmann J, Moter A, Willy C. The significance of biofilm for the treatment of infections in orthopedic surgery. Unfallchi­rurg. 2017;120:461–471. (In Germ.) doi: 10.1007/s00113-017-0361-y.
  35. Gostishchev VK, Omel'yanovskiy VV. Ways and possibilities of prevention of infectious complications in surgery. Khirurgiya. 1997;(8):11–15. (In Russ.)
  36. Printsipy organizatsii periope­ratsionnoy antibiotikoprofilaktiki v uchrezhdeniyakh zdravookhraneniya. Federal'nye klinicheskie rekomendatsii. (Organization perioperative antibiotic prophylaxis principles in healthcare facilities. Federal clinical guidelines.) Moscow: Natsional'naya assotsiatsiya spetsialistov po kontrolyu infektsiy, svyazannykh s okazaniem meditsinskoy pomoshchi; 2014. 42 p. (In Russ.)
  37. Kurtz SM, Ong KL, Lau E, Bozic KJ, Berry D, Parvizi J. Prosthetic joint infection risk after TKA in the medicare population. Clin Orthop Relat Res. 2010;468(1):52–56. doi: 10.1007/s11999-009-1013-5.
  38. Fujiwara T, Ebihara T, Kitade K, Setsu N, Endo M, Iida K, Matsumoto Y, Matsunobu T, Oda Y, Iwamoto Y, Nakashima Y. Risk factors of periprosthetic infection in patients with tumor prostheses following resection for musculoskeletal tumor of the lower limb. J Clin Med. 2020;9(10):3133. doi: 10.3390/jcm9103133.
  39. Fadeev EM, Bubnova NA, Sinenchenko GI, Tkachenko AN. Possibility of infectious complications prognosing after surgical interventions for a knee arthroplasty (publications overview). Health & education millennium. 2016;18(8):34–41. (In Russ.)
  40. Wang J, Zhu C, Cheng T, Peng X, Zhang W, Qin H, Zhang X. A systematic review and meta-analysis of antibiotic impregnated bone cement use in primary total hip or knee arthroplasty. PLoS One. 2013;8(12):e82745. doi: 10.1371/journal.pone.0082745.
  41. Borisov DB, Kirov MY. Endoprothesis replacement of hip and knee joints: epidemiological aspects and effect on quality of life. Ekologiya cheloveka. 2013;(8):52–57. (In Russ.) doi: 10.33396/1728-0869-2013-8-52-57.
  42. Morii T, Morioka H, Ueda T, Araki N, Hashimoto N, Kawai A, Mochizuki K, Ichimura S. Deep infection in tumor endoprosthesis around the knee: a multi-institutio­nal study by the Japanese musculoskeletal oncology group. BMC Musculoskelet Disord. 2013;14:51. doi: 10.1186/1471-2474-14-51.

Supplementary files

Supplementary Files
Action
1. JATS XML

© 2022 Eco-Vector





Согласие на обработку персональных данных с помощью сервиса «Яндекс.Метрика»

1. Я (далее – «Пользователь» или «Субъект персональных данных»), осуществляя использование сайта https://journals.rcsi.science/ (далее – «Сайт»), подтверждая свою полную дееспособность даю согласие на обработку персональных данных с использованием средств автоматизации Оператору - федеральному государственному бюджетному учреждению «Российский центр научной информации» (РЦНИ), далее – «Оператор», расположенному по адресу: 119991, г. Москва, Ленинский просп., д.32А, со следующими условиями.

2. Категории обрабатываемых данных: файлы «cookies» (куки-файлы). Файлы «cookie» – это небольшой текстовый файл, который веб-сервер может хранить в браузере Пользователя. Данные файлы веб-сервер загружает на устройство Пользователя при посещении им Сайта. При каждом следующем посещении Пользователем Сайта «cookie» файлы отправляются на Сайт Оператора. Данные файлы позволяют Сайту распознавать устройство Пользователя. Содержимое такого файла может как относиться, так и не относиться к персональным данным, в зависимости от того, содержит ли такой файл персональные данные или содержит обезличенные технические данные.

3. Цель обработки персональных данных: анализ пользовательской активности с помощью сервиса «Яндекс.Метрика».

4. Категории субъектов персональных данных: все Пользователи Сайта, которые дали согласие на обработку файлов «cookie».

5. Способы обработки: сбор, запись, систематизация, накопление, хранение, уточнение (обновление, изменение), извлечение, использование, передача (доступ, предоставление), блокирование, удаление, уничтожение персональных данных.

6. Срок обработки и хранения: до получения от Субъекта персональных данных требования о прекращении обработки/отзыва согласия.

7. Способ отзыва: заявление об отзыве в письменном виде путём его направления на адрес электронной почты Оператора: info@rcsi.science или путем письменного обращения по юридическому адресу: 119991, г. Москва, Ленинский просп., д.32А

8. Субъект персональных данных вправе запретить своему оборудованию прием этих данных или ограничить прием этих данных. При отказе от получения таких данных или при ограничении приема данных некоторые функции Сайта могут работать некорректно. Субъект персональных данных обязуется сам настроить свое оборудование таким способом, чтобы оно обеспечивало адекватный его желаниям режим работы и уровень защиты данных файлов «cookie», Оператор не предоставляет технологических и правовых консультаций на темы подобного характера.

9. Порядок уничтожения персональных данных при достижении цели их обработки или при наступлении иных законных оснований определяется Оператором в соответствии с законодательством Российской Федерации.

10. Я согласен/согласна квалифицировать в качестве своей простой электронной подписи под настоящим Согласием и под Политикой обработки персональных данных выполнение мною следующего действия на сайте: https://journals.rcsi.science/ нажатие мною на интерфейсе с текстом: «Сайт использует сервис «Яндекс.Метрика» (который использует файлы «cookie») на элемент с текстом «Принять и продолжить».