Association of blood level of inflammatory mediators and morphology of coronary artery stenosis in patients with stable angina
- Authors: Mahmudov RM1, Mammadov VS1, Mirzakhanova LR1
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Affiliations:
- Central Hospital of Oil Industry Workers, Baku, Azerbaijan
- Issue: Vol 95, No 3 (2014)
- Pages: 331-334
- Section: Theoretical and clinical medicine
- URL: https://ogarev-online.ru/kazanmedj/article/view/1507
- DOI: https://doi.org/10.17816/KMJ1507
- ID: 1507
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Abstract
Aim. To study the association of morphology of coronary artery disease and pentraxin-3, tumor necrosis factor α blood levels in patients with stable angina who undergo coronary artery bypass surgery. Methods. The study included 92 patients aged 44-73 years with stable angina of II-III functional class. The coronary artery disease type was classified by AHA/ACC criteria: type A - concentric stenosis with flat plague and plague length less than 10 mm, type B - eccentric stenosis or blunt-edged stenosis with moderate calcinosis or signs of mural trombosis, with length not exceeding 200 mm, type C - stenosis with plague length over 20 mm, plague ulceration, marked calcinosis, diffuse lesions, chronic coronary artery occlusion. Pentraxin-3, tumor necrosis factor α blood levels were measured by ELISA in all patients before the surgery, 8 and 24 hours after the surgery. Results. There was a relation found between the type of stenosis and pentraxin-3 and tumor necrosis factor α blood levels. In patients with С type stenosis, pentraxin-3 blood level was 4 times higher (p <0.001) 24 hours after the coronary artery bypass surgery compared to patients with A type stenosis, and by 1.8 and 1.3 times higher compared to patients with В1 and В2 stenosis type, accordingly. Conclusion. There was a close relation revealed between the morphology of coronary artery stenosis and pentraxin-3 and tumor necrosis factor α blood levels in patients with stable angina.
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##article.viewOnOriginalSite##About the authors
R M Mahmudov
Central Hospital of Oil Industry Workers, Baku, Azerbaijan
V S Mammadov
Central Hospital of Oil Industry Workers, Baku, Azerbaijan
Email: doktorvusal377@rambler.ru
L R Mirzakhanova
Central Hospital of Oil Industry Workers, Baku, Azerbaijan
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