卷 48, 编号 5S (1999)

Objective: predelivery prognosis of immunoconflict in the course of clinical observation of ABO-incompatible pregnancy.

Objective: To compare the efficacy of different types of IgG using in prophylactic and treatment of septic complications after Cesarean section.

Objective. The purpose of the study was to regulate the contractile activity of the uterus through the central nervous system and to have some psychotrophic effect.

Objective: To test hypothesis that plasmapheresis could be effective in complex therapy of primary antiphospholipid syndrome in women with recurrent pregnancy losses during pregnancy.

Materials that define the present situation of the teaching on intrauterine infections, of solved and unsolved problems of their diagnostics in mother and fetus are summed up in the report.

Objective: To assess condition of newborns in early neonatal period in comparison with results of immunomorphological investigation of placenta in mothers with genital chlamydiosis.

Objective: The aim of the research is the investigation of the microbiological characteristics of bacterial vaginosis (BV) in pregnant women.

Objective: the outcomes of researches conducted in Center by the employees of the department of neonatal pathology and the lab of clinical immunology have shown that the herpes-virus infection in the neonates develops on a background of immunodeficiency. The severity of infection clinical manifestations correlated with a decrease of specific antiviral antibodies level and the deficit of cells, inherings to T-helper subpopulation. The aim of the given research was the analysis of the specific humoral immunity condition in the neonates with a herpes-virus infection on a background of therapy.

Objective: To estimate the effect of nitric oxide donors on prolongation of pregnancy.

Objective: It is known that inflammatory process induced by infection increases nitric oxide (NO) synthesis as a result of cytokine activation of macrophages and endothelium cells. Oligopeptides as a products of protein catabolism usually appear in the urine due to intoxication of organism. The goal of the present work was to analyze the level of nitrites and nitrates (final products of NO metabolism) and oligopeptides excretion in intrauterine infected (IUI) newborns simultaneously with investigation of clinic status in early neonatal period.

Objective: The experimental study of the mechanism of non-specific character of the female reproductive system responce to xenobiotics possessing a neurotoxic (toluene, dioxane) or gonadotoxic effects (formaldehyde).

Insolvency of hepatocyte’s reserve possibilities, characterized by decrease of its synthetic function followed by qualitative and quantitative inner link of hemostasis defects, is one of the variants of organisms disadaptation for pregnancy and it is called “hepatodepressive syndrome” (HDS). This research was aimed to the investigation of dynamics of hemostasiological and bioëchemical parameters of blood, peculiarities of pregnancy, labour and perinatal outcome, developed in women with diagnosed laboratory markers of HDS beginning from the first or the second trimester of pregnancy.

Objective: to correlate the frequency of supraventricular tachycardia (SVT) in cases of WPW syndrome with gestational complications, fetal and newborn status.

We have observed the hormonal background in 160 patients with endometric hyperplasia on the background of the secondary ovarian sclerocystosis. The investigation has been carried out in the proliferatic stage of the menstrual cycle. It should be mentioned, that if the disease didn’t exceed 3 years, the data showed the affection of hypothalamic-hypophyseal system, which was accompanied with the increase of gonadotropic secretion.

Objective: To assess effectiveness of hyperbaric oxygenation (HBO) in intensive therapy of posthypoxic disturbances of cerebral bloodflow (DCB) in neonates.

Objective: The number of the cases of early ovarian cancer is determined with improvement of diagnostic methods, so working up of organ-preserving treatment is actual. The is no common opinion for managing of early ovarian cancer as yet.

Objective: To characterize the peculiarity of the course of pregnancy and labor in patients with hypersecretory diarrhea of infectious nature.

Objective. The aim of our investigation was the elaboration and introduction of the system of correlation conditions of threaten maternal mortality from Gestosis /G/ and Obstetrical bleeding /OB/.

In case an endometriosis patient has concomitant ulcer disease of the stomach and duodenum, it is necessary to exclude oral administration of hormones. Ignoring this recommendation leads to ulcer disease exacerbation; if the stomach is affected and treatment lasts for long (years), some unpleasant oncology sequels may occur.

Availability of foetal tissues at any stage of human embryonic development, started with fertilized oocyte supplemented by tremendous progress in molecular and cytogenetical techniques resulted in almost ultimate and efficient solution of all major problems concerned with PD of inherited disorders (ID). The treatment of ID should be considered as a next logic step in this direction.

With the purpose of definition of parameters cerebral circulation (CC) we used transcranial ultrasonic dopplerometria artery cerebra anterior (АСА) at 40 term infants in the age of 1-6 day (the scanner Aloka- 650, transducer 5 MHz) at children with the complicated current of the perinatal period (basic group - 32 children with neurology diseases, hypotrophia, infants of diabetic mothers) and control group (8 healthy newborns).

Objective. To reveal a specialty of central hemodynamic in development respiratory disorders in premature infants.

Objective: The purpose of this study was to examine the relationship between asymptomatic intrauterine infection and levels of proinflammatory cytokines in amniotic fluid, maternal and fetal blood.

Objective: Postoperative endometritis in puerperium is a grave risk factor to mother’s invalidization and mortality. Preventive application of antibiotics leads to asymptomatic onset of the disease and delay of the full value complexive therapy.

Purpose: to improve immediate and distant results of surgical treatment in women with myoma of uterus combined with genital endometriosis and/or endometrial hyperplasia.

Objective: We report our experience to determine value of colored and pulsed Doppler sonography in diagnosing between benign and malignant ovarian tumors.

A comparative study of the immune status of the inhabitants of the plain with the maritime climate being changed to the continental one (the Kaliningrad, Alma-Ata regions) and the natives of highlands (Zailijskij Alatau and the Pamirs) has boon undertaken.

The indices of the immune status for the Kaliningrad and Leningrad region inhabitants were found to be the following: SD3 content equals 45,3±1,6%, SD4 — 20,2±1,2%, SD8 ±14,7±0,9%, SD16 ±9,1%, SD4/SD8 relationship makes up 1,4±0,13. The relevant values for the foothills and highlands inhabitants showed more considerable fluctuations due to the climatic discomfort.

Objective: Propyphenazone one of the pirazolon derivatives is widely used analgesic and antipyretic medicine. The purpose of this study was to evaluate propyphenazone effect on fetal liver after administered to maternal animal model.

Objective: to make a comparison of vitamins (VIT) and erythropoietin (EPO) concentrations between pregnants with and without anemia. 18 anemic pregnants were included to the main group. The control group consisted of 20 pregnants without anemia. The serum immunoreactive EPO was measured using the ProCon EPO 24 set (St.- Petersburg, Russia). Serum levels of VIT: retinol (A); tocopherol (E); ascorbic acid (C); riboflavin (B₂); pyridoxin (B₆); в carotin (в Car.); S carotinoids(S Car.) were measured.

Objective: to study the changes in lipid levels in high-risk pregnant supplemented with n-3 polyunsaturated fatty acids (PUFA).

Objective: To evaluate clinical condition and platelet hemostasis in diabetic mothers and their neonates.

Objective: To study the effect of intraoperational reinfusion on the onset and duration of lactation in parturient after an operation of cesarean section.

Pregnant women with the contracted pelvis belong to the «high risk» group of perinatal pathology. Anatomically and clinically contracted pelvis is one of the frequent indications for cesarean section.

Aim: The main aim of the study was hormonal analysis of the menstrual cycle among infertile women with endometriosis.

Objective: Endometrial cancer are shown is nonequallical by histotypical structure, differented adenocarcinoma were observed in most of ones. The aim of our data was to investigate one of the rarest form of endometrial cancer such as uterine papillary serous carcinoma (UPSC).

Objective. To study revelation rate of a combined pathology of genitals, thyroid and mammary glands among the conditionally healthy women with sonographic screening.

Purpose: To carry out an expertise of prior medical documents died from gestosis to reveal modern clinical aspect of gestosis.

Objective: Intrauterine device (IUD) is the most popular method of female contraception. The aim of this study is the quest of new treatment modality, contrary to routine antibacterial method.

Objective: The necessity to study nephrogenic in pregnancy is mandated by a continuing increase of number of patients affected by that disorder.

Objective: Rising rates of cesarean sections (C.S.) in many countries have been of a wide concern. The objective of this report is to analyze the current knowledge about the advantages and disadvantages of abdominal delivery.

Objective: To evaluate the frequency, the peculiarities of the course of early neonatal period and the results of the treatment newborn infants infected with Chlamydia trachomatis.

The development of technology to care of very low birth-weight infants is the cause of survival of these patients. In intensive care the mortality of premature infants’ unit with birth weight <1000 was decreased from 64% to 40% and with birth weight 1001-1500g was decreased from 40% to 27%. But it is known, that decrease of mortality in some group of this patients creates other serious problem - the quality of future life. The purpose of this study was to determine how low grade of prematurity would influence on rate intraventricular hemorrhage (IVH), retinopathy of premature (ROP) and bronchopulmonary dysplasia (BPD).

Objective: Patients with primarily inoperable, advanced cervical cancer- should be brought into an operable stage. Selective angiography and preoperative application of cisplatin into both artery uterine is a therapeutic option with low risks and side effects by this intraarterial application a significant higher intratumoral cisplatin concentration can be reached in comparison to systemic application of cisplatin.

Objectives: The goal of the present work was to analyze the role of immune complexes and NO-synthase activity of placenta in pathogenesis of gestosis.

Objective: The work was aimed at the elaboration of the diagnostic criteria of endotoxicosis during pregnancy, previous to the development of postnatal sepsis.

Objective: improvement of pathological bleeding causes diagnostics (PBS) in women of the reproductive age.

Objective: To evaluate if the humerospinous distance as an indicator of shoulder width could be used to predict shoulder dystocia at term.

Objective. To assess if the criteria for perinatal mortality and outcome of diabetic pregnancy had been met in a small and well-developed island society, Iceland. The aim of the St. Vincent declaration of WHO is that the same pregnancy outcome for diabetic and поп-diabetic women should be achieved.

Objective: To investigate the impact of the subdermal contraceptive Norplant on the condition of hormonally dependent organs (cervix of the uterus, mammary glands, endometry) in women of various ages and acceptance rates.

Objective. To estimate the role of hormone-dependent changes of the microrelief of endometrial epitheliocytes in pathogenesis of infertility associated with peritoneal endometriosis.

Objective: Anti-cardiolipin antibodies (aCL) associated with various obstetric complications and subject to thrombosis of placental vessels. aCL associated with thrombosis does not directly bind to CL itself, but to b₂-glycoprotein I (b₂-GP I) which attached to CL. Our purpose was to study the actions of aCL and anti-cardiolipin b₂-glycoprotein I complex antibodies (anti-CEb₂-GP I) on pregnancy outcomes.

Objective: to investigate influence of the transdermal estrogen — CLIMARA on clinical, hormonal and sonographic features in hypergonadotropic and normogonadotropic ovarian insufficiency patients.

Objective: The purpose of this study was evaluating the role of dishormonal diseases of the thyroid and mamma in patients with pelvic masses and adenomyosis to developing the treatment strategy for this patient population.

Objective: to value efficiency of septic complications after sectio Caesarea and episiotomy prophylactic by local application of meksidol.

We retrospectively reviewed 156 cases of pT2-mammacarcinomas (Tumor size 2-5 cm) who were treated between 01.01.93 and 01.10.97 in our hospital. We evaluated in how main cases and with the usage of which techniques we were able to perform breastconserving surgery.

Objective: to access the possibilities of operative hysteroscopy. Many hysteroscopic operations make it possible to avoid hysterectomy thus preserving menstrual and reproductive functions. Besides medical problems intrauterine (IU) hysteroscopic surgery helps to improve psychoemotional status of these patients.

A change of the level of (CoHb) in blood of pregnant women is one of the factors of obstetrics and perinatal complications. Influence of CoHb level on the emergence of fetoplacental deficiency was proved in experiments on the chronic hypoxia model (Nazyrov A.T., Israilova M.Z.).

In this work are presented the dates about the improvement of the treatment efficiency for the barren couples by the application to the composite therapy the peptide bio-regulators: medicinal preparations (timaline, timogene) and biology-active additions to the food (prostalamine, testolamine).

Objective: Sexually transmitted diseases (STD) are shown are the most frequent causes of inflammatory form of urogenital system and some patients with STD have psychological problems, which are required consultation of psychiatrist. Than 30 non-pregnant women with STD were tested to detected of peculiarities of psychological status.

Objective: Labor is a unique physiological process accompanying with a pain. Hence adequate analgesia in labor is the important factor of regulation of delivery. However, despite of physiologically substantiated opioid analgesia the efficiency in labor is small. The purpose of work was the definition of the factors influencing efficiency opioid analgesia of different groups.

Objective: To compare dynamic of S/D ratio in ductus venosus (DV) with one in inferior vena cava (IVC) during normal pregnancy.

The value of the quality of intestine preparation was conducted on 70 patients with different gynecologic diseases needed for operative intervention. All patients were divided on 2 groups by the methods of preparation. 1 group — traditional methods (37 patients); 2 group — with using of Macrogo I 4000 (Fortrans) (33 patients).

Objective: To estimate progestogenic activity of new synthetic compounds - analogues of 17a-hydroxyprogesterone and their capable to maintain the pregnancy in the rabbits experiments.

Objective: To study postoperative complications risk after multifetal pregnancy reduction (MFPR).

Objective and methods. Research was undertaken aiming at determining what effect the condition of the endometrium on the day of the HG injection has on the results of the IVF.

Objective: To explore the level of magnesium in the maternal serum, the umbilical serum and the amniotic fluid in the third trimester of pregnancy and during the C-section.

Objective: To investigate the possibility of using capnography for pre-clinical diagnostics of pathophysiological mechanisms of respiratory disorders.

The purpose of our study: summarizing the results of an operating delivery for last 20 years. During last 20 years in Russia the frequency of cesarean section under the perinatal indications was increased almost twice. However, analysis, conducted by us, has not revealed a correlation between frequency of an operating delivery and both levels of perinatal mortality and morbidity.

With the purpose of optimization of anesthetization in gestosis patients during labor the parameters of central hemodynamic and cerebral blood flow has been investigated. The patients have been compared in anesthesiology methods during labor and deviated in 3 groups.

Objective: The optimal regimen of medical termination of the second trimester pregnancy is still under development, but it likely to be characterized by a short induction-to-abortion interval, low incidence of side-effects and high acceptability.

Objective: Investigation of the influence of Mildronatum on hemodynamics in the “mother-placenta-fetus” system with different degrees of its circulatory disorders in 21 women in the III trimester of pregnancy.

Color Doppler sonography can be successfully used for the assessment of the intervillous circulation throughout the three trimesters of pregnancy. The first trimester pregnancies were assessed by the transvaginal route while second and third trimesters pregnancies were evaluated using transabdominal route. Color flow mapping was used for visualization of the outlets of the spiral arteries into the intervillous space and the blood flow inside it. Pulsatile, arterial-like intervillous flow signals and spiral arteries signals were assessed by the use of pulsed Doppler and expressed by resistance (RD and pulsatility (PD indices, peak systolic velocity (PSV), end-diastolic velocity (EDV), and temporal averaged maximum velocity (TAMV). Velocities of blood flow of pulsatile signal in the intervillous space increased significantly towards the mid-pregnancy.

The treatment of ovarian cysts remains one of the main problems in gynecology, the densities of unjustified surgical interventions is still high. The results of treatment 588 patients (average age 38,5 years) which the puncture of ovarian formations under the control of US are given. The indications to realization of intervention were the combinations of an oothecoma to infringements of a menstrual cycle and/or by a pain set of symptoms in the genesial period; with the expressed adhesive process of a small basin after cavitary operations and high risk of postoperative complications; with a serious extragenital pathology in postmenopause.

Objective: To prepare the endometrium to stimulation ovulation cyclic hormonal therapy was administered to infertile women with POS: the 1-st group of patients (n=6) received glucocorticoids; the 2-nd group (n=9) received gestagens; the 3-rd group (n=5) received both gestagens and glucocorticoids. Thirteen patients with POS who didn’t get any therapy were considered as a comparison group (4-th group) and 5 fertile women became a control group.

Objective: our original strategy for PD of chromosome disorders includes analysis of direct chromosome preparations from CVS as the basic step, supplemented with CBL cultures for karyotyping of the fetuses with abnormal or ambiguous CVS results.

In order to outline factors affecting the neonatal weight we analyzed the course and outcome of 227 pregnancies in women with insulin dependent diabetes mellitus (IDDM) who gave birth to liveborn babies in 1989-1997years. Mean age of patients was 24.9±0.3 years, mean duration of diabetes 10.5±0.4 years. In 88 women (38.8%) microvascular diabetes complications were present. The transition from conventional to intensive insulin therapy took place on the average at 13.6±1.2 weeks of pregnancy.

Objective: to evaluate the influence of antenatal thyrotropin-releasing hormone and glucocorticoids therapy for prevention of respiratory distress syndrome and for survival rate in group of prematurely born very low birth weight infants (<=1500g).

When uterine myomas are enucleated by pelviscopy (laparoscopy), it is more difficult to find all myomas and to close the hysterotomy than in laparotomy. It has been proposed that later pregnancies are more prone to complications, in particular uterus rupture, and that amelioration of symptoms is inferior. Since 1988, we have performed more than 95% of the myomectomies in our clinic by pelviscopy. In the years 1995-1999, we sent questionnaires to 1143 patients who had undergone an enucleation of uterine myomas at least 2 years previously.

Objective: to study the gynecological morbidity of schoolgirls and to compare it with the data of the other regions.

Surfactant. In 1957 Clements isolated from lung tissue a surface-active material which he called surfactant. It is composed of phospholipid with small amounts of neutral fat, cholesterol, and protein. The primary active molecule is saturated dipalmytoyl phosphatidylcholine. Other components of surfactant, including unsaturated phosphatidylcholine and phosphatidylglycerol, are important in making surfactant more fluid and facilitating re-spreading. Surfactant lowers surface tension by adsorbing to surface and displacing water molecules. In the lung, the presence of surfactant counteracts the tendency of the lung to collapse at the end of breath, allowing a functional volume of gas to remain in the lung at the end of expiration (functional residual capacity).

Postnatal care of the immature lung. There are two principal goals in postnatal care of immature lung: 1) to replace an endogenous surfactant deficit; 2) to maintain adequate ventilation (effective lung recruitment) with minimal damage of the immature lung.

The majority of a very low-birth-weight (VLBW) babies (<1500 g) due to their immaturity need special support and often intensive care. The main problems of the VLBW babies are primarily related to the varying degree of physiological immaturity of several organ functions. These premature infants may be particularly vulnerable to stressful effects of the Neonatal Intensive Care Unit (NICU) environment. In addition, acutely ill premature infants have a little ability to cope with stressful experiences because of their immaturity and lack of physiological reserves.

The infertile marriage represents the serious medical-social problem. The development of the modem methods of diagnosis permits to determine the main causes of infertility and to solve the problem of the choice of treatment method in time. The structure and main causes evoking the aphoria on patients of dispensary group in Center of human reproduction, definition of couple's group can be treated by IVF method were the main purposes of research.

Objective: To study a microbial spectrum at the development of endometritis and metroendometritis in early and late postpartum periods.

Objective: The different methods such as medical, physiotherapeutic and others use for prevention of postabortion complications in modern gynecology.

Objective. Oral steroid contraceptives were marketed in the United States in 1960s. They became one of the most widely used methods of reversible contraception in developing countries. Oral contraceptives are being used every day by more than 50 mln women around the world for the prevention of unwanted pregnancy as well as by women in replacement therapy. Estrogen replacement offers significant benefits to many postmenopausal women. The benefits and risks as they pertain to each individual patient should be reviewed with her in details. The aim of this study was to establish the influence of estrogen therapy on parenchyma of liver. The first descriptions of a relationship between Replacement Hormonal Therapy (RHT) use and the development of benign hepatic lesions were reported in early 1970s. Histopathologic diagnosis of benign liver tumors has been reported as focal nodular hyperplasia adenoma, solitary hyperplastic nodule and focal cirrhosis. Investigation of the possible relationship between HRT and liver cancer has provoked considerable controversy. Synthetic sex steroids are believed to potentate cholestasis, hypervascularity, microsomal enzyme induction.

Objective: Our purpose was to study the hysterectomy influence (in women of reproductive age) to the ovarian function, lipid metabolism and the possibility to corregate the complaints using HRT.

To diagnose persistent infection, we used transcervical chorion biopsy (generally accepted method) with the following bacteriology of bioptates of 70 patients with habitual abortion in 8-10 weeks of pregnancy.

In order to allocate adequate resources for health care of gynecological infections (G.I.), a reliable surveillance program, is mandatory. Also, to be able to propose screening programs and to be able to calculate the cost-effectiveness of such initiative (which may even gain money to the society) even in a short-term perspective. To be able to recommend therapy in syndrome-based management of G.I. and to propose a reasonable battery of tests to work-up cases consulting with symptoms that can be assumed to be caused by such infections, etiologically studies should be performed at regular intervals in each hospital (or regional) catchment area.

Objective: The study analyzes the incidence and management of postoperative lymphatic cysts.

The parameters of central hemodynamic and cerebral blood flow have been investigated in 40 health puerperas and in 125 puerperas with gestosis. 35 with light degree nephropathy (1 group), 40-with middle degree (2 group), 50-with grave nephropathy (3 group). The investigated has been realized on 1, 2, 3, 5, 8 and 10 days after delivery. In most cases (80%) the delivery was spontaneous, in 20% of cases the delivery was proceed by the cesarean section.

Objective: To study the efficiency of Instenon (preparation consisting of 3 substances possessing vasoactive and metabolically active properties: ethophylline, hexobendine and etamivane) used for antepartum preparing pregnant women of a risk group for the development of abnormal labor activity.

Objective: To establish the possible influence of multifetal pregnancy reduction on venous circulation in fetuses continued their development.

Objective. Formation correlation between thermoregulation and cyclic state organization in healthy infant and in infants with perinatal pathology were studied.

Objective: To study the efficacy of recombinant FSH ovulation induction in normogonadotropic infertile women.

Objective: This communication describes the role of immunotherapy in management of vaginal infectious diseases. We tested the effects of local treatment with Cycloferon-liniment (synthetic interferon inducer, Russia) in patients with vaginal candidosis, nonspecific bacterial vaginitis and bacterial vaginosis.

Objective: To study the efficiency of treating dysfunctional uterine bleedings in patients of premenopausal period by Primolut-nor (Germany), each tablet of which contains 5 mg or 10 mg of noretysterone. 74 patients were observed at the age of 40-52 years.

At Danderyd Hospital, the deliveries amount to around 5 000 per year. The delivery department is divided into two sections. In the section for normal deliveries there are six labour rooms. The patients, who go to that part, are carefully selected: women with uncomplicated pregnancies between 38 and 42 weeks of gestation, and a normal start of labour. In the other section, comprising 8 delivery rooms, all other patients are tended to. The midwives alternate between both sections, usually for one year at a time.

Preterm birth is one of the greatest unsolved problems in modem obstetrics. It has been showed that intraamniotic infection (IAI) from microorganisms found in the lower genital tract are implicated both in the etiology and in the complications of preterm birth. In Lithuania this problem is particularly severe, since the prevalence of genital and particularly sexually transmitted diseases (STD) is high. At the Department of Obstetrics and Gynecology of Kaunas Medical University Hospital, a tertiary-care perinatal referral center, the studies on preterm labor and infection were performed during period 1992 - 1996.

Biological qualities of women's milk promote fast adaptation of born to extrauterine existence. Placental lactogen (PL) influences the receptors of prolactin to support high level of carbohydrates in milk. The synthesis of proteins and lipids of milk is made under the stimulating influence on mamma estriol (E3) and progesteron (PG).

Objective: To study the efficacy of Ginkor Fort (“Beaufour”, France) in treatment of chronic venous insufficiency in 40 pregnants with viral and/or bacterial infection in the 3rd trimester of gestation.

Objective: Sarcomas of uteri are rare tumors, 0,7 cases among 100 000 female population. Developing interstially tumors is characterized by early and rapid metastatic spread. Than we identified clinical and pathological specialties of diagnosis, treatment, follow-up and prognosis form patients with sarcomas of uteri.

In our earlier study (Gogoberidze N. V., Papitashvili A.M. «School of Fundamental Medicine Journal», 1996, v.2, N1, 92-93) using mathematical theory of information, we have defined based on the mathematical modeling the informative theory of ontogenesis periodization. There was get answer of equation concerning ontogenesis periodization.

Objective: fetus conditions diagnostic optimization by pregnant in gestosis.

Objective: To analyse obstetrical and perinatal outcomes in newborns of diabetic mothers in Perinatal Center for Diabetic Pregnant Women in Lublin.

Objective and methods: Laparoscopy and hysteroscopy were carried out in 37 patients following unsuccessful attempts at IVF since 1995. The following abnormalities were diagnosed: bilateral sapingitis - 18 cases, external genital endometriosis - 15, endometrial pathology - 10, uterine myoma - 5 and combined pathology - 24.

Objective: Efficacy and tolerance of levonorgestrel and combine estrogen-gestagen oral contraceptive regimen of emergency contraception (EK) in fertile women was studied.

The pathology of extraembryonic structures (ES) (placental bed (PB), placenta, amniotic fluid (AF), umbilical cord (UC) and their influence on perinatal outcomes remains poorly understood, despite of the priority role they play in maintenance of fetoplacental system (FPS) homeostasis from nidation until delivery. The intensive study of placenta and its insufficiency (PI) in 70-80^th was basically dedicated to investigation of its structure and function in II-III trimesters and has not revealed structural and metabolic features of interrelations ofphysiological and pathological changes of ES and its influence on maternal and fetal status. In this message the results of long-term investigations of adaptational and homeostatic characteristics of ES are submitted.

In many respects, the results of the IVF crucially depend on the joint condition of an endometrium and a uterus at the moment of embryo implantation. The influence of the most significant among them, for example, of endogenic oestradiol, may be unsufflcient. That is what have been confirmed by the results of ultrasound testing. To increase the readiness of endometrium for the embryo implantation and further supplementation of early pregnancy we have used the medicine, analogous of the native oestradiol, Estrofem T (Novo Nordisk, Denmark). 

Plasmapheresis, being one of the extracorporal therapy methods, was included to comprehensive preparation of 24 pregnant women for cesarean section operation. Therapy tactics was selected due to according pathology and its severity. Instead of plasma being removed the patients were administered crystalloid solutions. Donor blood drugs (plasma, albumin) were not used.

The menopause is accompanied by changes of lipid profde and some parameters of hemostasis. These changes are results of estrogen deficiency and aging. Some women become menopausal in younger age, in premenopausal or reproductive period of their life, by surgical removal of ovaries with or without hysterectomy. We evaluate the serum concentrations of gonadotropins, sex steroids, cholesterol, triglicerids, LDL, HDL, fibrinogen in 66 women with surgical menopause and effectiveness of hormone replacement with estrofem, kliogest and trisequence. We used combined (continuous and sequential) therapy in those women after hysterectomy who underwent surgery because of endometriosis.

Objective and Methods. 150 women with diffuse non-toxic goitre (DNG) age 19-42 and 80 healthy women of the same age were examined with ultrasonic determination of thyroid volume, colpocytology, basic thermometry, serum levels of gonadotropins, prolactine, thyroid hormones, estradiol, progesterone by immunofermentic method.

Objective: To study the influence of laparoscopic treatment of pelvic endometriosis on the ovarian function.

Objective: To reveal the unfavorable factors in prenatal period influential in becoming menstrual function of the girl with big birth weight.

Method: Analysis the changes of reproductive women’s health in Lithuania is performed in this abstract. For this reason, are used official statistical data and references.