电邮这篇文章 育龄妇女食饵性肥胖治疗对卵巢瘦素水平及激素功能的影响
- 作者: Riazantceva E.М1, Tarasova M.A.2, Tkachenko N.N.2, Gzgzyan A.M.2
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隶属关系:
- Clinical Diagnostic Medical Center of the Office of the President of the Russian Federation
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- 期: 卷 69, 编号 3 (2020)
- 页面: 17-26
- 栏目: Original study articles
- URL: https://ogarev-online.ru/jowd/article/view/30141
- DOI: https://doi.org/10.17816/JOWD69317-26
- ID: 30141
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详细
研究现实性：30%以上体重超标和肥胖的育龄妇女存在卵巢功能不全。关于瘦素对生殖系统、卵巢激素生成和卵巢激素不全食饵性肥胖女性的显著影响的数据被提出。肥胖治疗对纠正高瘦素血症和恢复激素和排卵功能的育龄妇女食饵性肥胖的效果是值得关注的。
目的是研究肥胖治疗对育龄妇女瘦素水平和卵巢激素功能的影响。
材料与研究方法。所有的妇女都进行了临床和实验室检查，包括病史信息、人体测量学（测量身高和体重，腰围和臀围，计算身体质量指数），血压测量、妇科检查、测定促性腺激素、性激素、胰岛素、血瘦素、血生化参数、空腹血糖和糖耐量试验，盆腔超声、全身骨密度测量仪。调查数据和客观调查数据被录入专门设计的问卷，其中包括以下指标：患者的年龄、初潮的年龄、月经周期的性质、怀孕、分娩和生殖计划的数据、妇科和躯体疾病。
研究成果。研究了体重减轻后瘦素、雌二醇、卵巢卵泡数与排卵功能恢复的关系。建立了一个数学模型来估计体重减轻后排卵恢复的概率。分析了二甲双胍、西布曲明治疗对减肥后排卵恢复的影响。
结论。获得的结果使我们能够确定体重减轻后因超重和食饵性肥胖导致无排卵的患者血液中瘦素和雌二醇指标、窦卵泡数量和胰岛素抵抗与实现排卵相关的预后价值。对比服用药物治疗食饵性肥胖的妇女与服用二甲双胍和西布曲明的妇女，排卵恢复的频率没有显著差异。
作者简介
Ekaterina Riazantceva
Clinical Diagnostic Medical Center of the Office of the President of the Russian Federation
编辑信件的主要联系方式.
Email: emr4@yandex.ru
SPIN 代码: 3500-9510
Scopus 作者 ID: 859980
MD, Head of the Department of Obstetrics and Gynecology
俄罗斯联邦, Saint PetersburgMarina Tarasova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: tarasova@ott.ru
SPIN 代码: 8166-3356
Scopus 作者 ID: 507261
MD, Head of the Department of Obstetrics and Gynecology
俄罗斯联邦, Saint PetersburgNatalia Tkachenko
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: liberin@mail.ru
ORCID iD: 0000-0001-6189-3488
SPIN 代码: 9633-6701
Researcher ID: K-1734-2018
PhD, Head of the Laboratory of Endocrinology. The Department of Endocrinology of Reproduction
俄罗斯联邦, Saint PetersburgAlexander Gzgzyan
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: agzgzyan@gmail.com
SPIN 代码: 6412-4801
MD, PhD, DSci (Medicine), Professor, Head of Reproduction Department
俄罗斯联邦, Saint Petersburg参考
- Мишарина Е.В., Абашова Е.И., Потин В.В. Ожирение и репродуктивная функция женщины // Журнал акушерства и женских болезней. − 2016. − Т. 65. − № 5. − С. 64–74. [Misharina EV, Abashova EI, Potin VV. Obesity and ovarian insufficiency. Journal of obstetrics and women’s diseases. 2016;65(5):64-74 (In Russ.)]. https://doi.org/10.17816/JOWD65564-74.
- Баланова Ю.А., Шальнова С.А., Деев А.Д., и др. Ожирение в российской популяции — распространенность и ассоциации с факторами риска хронических неинфекционных заболеваний // Российский кардиологический журнал. − 2018. − Т. 23. − № 6. − C. 123–130. [Balanova YuA, Shal’nova SA, Deyev AD, et al. Obesity in Russian population — prevalence and association with the non-communicable diseases risk factors. Russian journal of cardiology. 2018;23(6):123-130. (In Russ.)]. https://doi.org/10.15829/1560-4071-2018-6-123-130.
- Dağ ZÖ, Dilbaz B. Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc. 2015;16(2):111-117. https://doi.org/10.5152/jtgga.2015.15232.
- Подзолкова Н.М., Колода Ю.А., Подзолков А.В. Терапия бесплодия у пациенток с ожирением: современный взгляд на проблему // Проблемы репродукции. − 2012. − Т. 18. − № 3. − С. 37–41. [Podzolkova NM, Koloda YuA, Podzolkov AV. INFertility therapy in obese patients: modern trends. Problemy reproduksii. 2012;18(3):37-41. (In Russ.)]
- Синдром поликистозных яичников / под ред. И.И. Дедова, Г.А. Мельниченко. – М.: МИА, 2006. – С. 242−272. [Sindrom polikistoznykh yaichnikov. Ed by I.I. Dedov, G.A. Mel’nichenko. Moscow: Meditsinskoye informatsionnoye agentstvo; 2006. Р. 242-272. (In Russ.)]
- Khaskheli MN, Baloch S, Baloch AS. Infertility and weight reduction: influence and outcome. J College Physicians Surgeons Pakistan. 2013;23(10):798-801. https://doi.org/ 11.2013/JCPSP.798801.
- Pandey S, Pandey S, Maheshwari A, Bhattacharya S. The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci. 2010;3(2):62-67. https://doi.org/10.4103/0974-1208.69332.
- Comninos AN, Jayasena CN, Dhillo WS. The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update. 2014;20(2):153-174. https://doi.org/ 10.1093/humupd/dmt033.
- Catteau A, Caillon H, Barrière P, et al. Leptin and its potential interest in assisted reproduction cycles. Human Reproduction Update. 2016;22(3):320-341. https://doi.org/10.1093/humupd/dmv057.
- Мишарина Е.В., Потин В.В., Боровик Н.В., Тиселько А.В. Лечение недостаточности яичников у больных с ожирением // Signatura. − 2007. − № 2. − C. 46–51. [Misharina EV, Potin VV, Borovik NV, Tisel’ko AV. Lechenie nedostatochnosti jaichnikov u bol’nyh s ozhireniem. Signatura. 2007;(2):46-51. (In Russ.)]
- Калинкина О.Б. Влияние снижения массы тела на факторы риска сердечно-сосудистых заболеваний и репродуктивную функцию у пациенток с метаболическим синдромом // Ожирение и метаболизм. − 2015. − Т. 12. − № 2. − С. 14–18. [Kalinkina OB. Impact of body mass decrease of patients with metabolic syndrome on cardiovascular risk factors and reproductive function. Obesity and Metabolism. 2015;12(2):14-18. (In Russ.)]. https://doi.org/10.14341/OMET2015214-18.
- Holte J, Bergh T, Berne C, et al. Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J Clin Endocrinol Metabol. 1995;80(9):2586-2593. https://doi.org/10.1210/jcem.80.9.7673399.
- Wadden TA, Foster GD. Behavioral treatment of obesity. Med Clin North Am. 2000;84(2):441-461. https://doi.org/10.1016/s0025-7125(05)70230-3.
- Bray GA. Uses and misuses of the new pharmacothe¬rapy of obesity. Ann Med. 1999;31(1):1-3. https://doi.org/10.3109/07853899909019257.
- Galazis N, Galazi M, Atiomo W. D-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review. Gynecol Endocrinol. 2011;27(4):256-262. https://doi.org/ 10.3109/09513590.2010.538099.
- Froment P, Touraine P. Thiazolidinediones and fertility in polycystic ovary syndrome (PCOS). PPAR Res. 2006;2006:73986. https://doi.org/10.1155/PPAR/2006/73986.
- Nieuwenhuis-Ruifrok AE, Kuchenbecker WK, Hoek A, et al. Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis. Hum Reprod Update. 2009;15(1):57-68. https://doi.org/10.1093/humupd/dmn043.
- Upadhyaya P, Rehan HS, Seth V. Serum leptin changes with metformin treatment in polycystic ovarian syndrome: correlation with ovulation, insulin and testosterone levels. EXCLI J. 2011;10:9-15.
- Мишарина Е.В., Бородина В.Л., Главнова О.Б., и др. Инсу¬линорезистентность и гиперандрогенемия // Журнал акушерства и женских болезней. − 2016. − Т. 65. − № 1. − C. 75–86. [Misharina EV, Borodina VL, Glavnova OB, et al. Insulin resistance and hyperinsulinemia. Journal of obstetrics and women’s diseases. 2016;65(1):75-86. (In Russ.)]. https://doi.org/10.17816/JOWD65175-86.
- Clinical gynecologic endocrinology and infertility. Ed. by L. Speroff , R.H. Glass, N.G. Kase. 6th ed. Baltimore: Lippincott, Williams & Wilkins; 1999.
- Тарасова М.А., Барабанова Л.В., Лекарева Т.М., и др. Применение анорексигенного препарата центрального действия в сочетании с эстроген-гестагенным контрацептивом для лечения ожирения у женщин // Журнал акушерства и женских болезней. − 2010. − Т. 59. − № 3. − С. 76–82. [Tarasova MA, Barabanova LV, Lekareva TM, et al. Combined use of anorectic drug of central action and estrogen-gestagenic contraceptive preparation for the treatment of obesity in women. Journal of obstetrics and women’s di¬seases. 2010;59(3):76-82. (In Russ.)]
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