Evaluation of the effectiveness of innovative methods of focused ultrasound and uterine artery embolization in the treatment of uterine fibroids

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BACKGROUND: Uterine fibroids are one of the most common gynecological diseases. The application of innovative techniques such as focused ultrasound ablation and uterine artery embolization has improved the quality of life of many patients. However, despite significant advances in innovative therapies, there is no certainty about the long-term efficacy of focused ultrasound ablation and uterine artery embolization.

AIM: The aim of this study was to compare the efficacy of focused ultrasound ablation and uterine artery embolization treatments of uterine fibroids.

MATERIALS AND METHODS: This study analyzed observations of 112 patients with uterine fibroids. Patients in the first group were treated with focused ultrasound ablation (n = 44). The second group of patients underwent uterine artery embolization (n = 68).

RESULTS: The study groups differed in the reduction of myomatous node sizes one, three, six and 12 months after surgery, depending on the chosen treatment method (p < 0.001). In the first group, fibroid volume decreased by 14% after a month and by 35% after 12 months. In the second group, it decreased by 20% after a month and by 54% after a year.

CONCLUSIONS: Treatment with the uterine artery embolization method reduced fibroid volume by 54%, which is 19% more effective than the focused ultrasound ablation method.

作者简介

Lyudmila Kaushanskaya

Rostov State Medical University

编辑信件的主要联系方式.
Email: ludmila_kaushanskaya0912@mail.ru
ORCID iD: 0000-0002-5065-0066
SPIN 代码: 2142-2127

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Rostov-on-Don

Zareta Gatagazheva

Ingush State University

Email: zaretapoin66@yandex.ru
ORCID iD: 0000-0001-8067-378X
SPIN 代码: 4643-6804

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Magas

Zukhra Uzdenova

H.M. Berbekov Kabardino-Balkarian State University

Email: elifiya@bk.ru
ORCID iD: 0000-0003-0371-2671
SPIN 代码: 9296-8074

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Nalchik

Malika Gatagazheva

Ingush State University

Email: ing_gu@mail.ru
ORCID iD: 0000-0002-6010-0287

MD, Cand. Sci. (Med.), Assistant Professor

俄罗斯联邦, Magas

Khava Arsanukaeva

A.A. Kadyrov Chechen State University

Email: arsunukaeva29@gmail.ru
ORCID iD: 0009-0000-7970-2889
俄罗斯联邦, Grozny

Nesredin Makhmudov

Rostov State Medical University

Email: vip.nesred@mail.ru
ORCID iD: 0009-0002-4648-869X
俄罗斯联邦, Rostov-on-Don

Darya Minigulova

Regional Children’s Clinical Hospital

Email: daryaploxova@mail.ru
ORCID iD: 0009-0008-0726-3352
俄罗斯联邦, Stavropol

参考

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  2. Stewart EA, Gedroyc WM, Tempany CM, et al. Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol. 2003;189(1):48–54. doi: 10.1067/mob.2003.345
  3. Slabozhankina EA, Kitaev VM, Kira EF. The effectiveness of ultrasound hifu-ablation of uterine fibroids, depending on the type of MR fibroids. Bulletin of the National Medical and Surgical Center named after N.I.Pirogov. 2015;10(1):51–55. EDN: WMPBTP
  4. Sosnova EA, Malysheva YR. Methods of the treatment of uterine myoma: Literature review. V.F. Snegirev Archives of Obstetrics and Gynecology. 2017;4(1):20–28. EDN: XWKTQT doi: 10.18821/2313-8726-2017-4-1-20-28
  5. Edwards RD, Moss JG, Lumsden MA, et al. Uterine-artery embolization versus surgery for symptomatic uterine fibroids. N Engl J Med. 2007;356(4):360–370. doi: 10.1056/NEJMoa062003
  6. Devyatova EA, Tsaturova KA, Esmurzieva ZI, et al. Uterine myoma. Obstetrics and gynecology: news, opinions, training. 2015;(3):80. (In Russ.) EDN: VNTCGD
  7. Kim HS, Baik JH, Pham LD, Jacobs MA. MR-guided high-intensity focused ultrasound treatment for symptomatic uterine leiomyomata. Acad Radiol. 2011;18(8):970–976. doi: 10.1016/j.acra.2011.03.008
  8. Politova AK, Kira EF, Bolomatov NV, et al. Comparative evaluation of combined and isolated applications of high-intensity focused ultrasound and super-selective uterine artery embolization in treatment of patients with uterine fibroids. Journal of Obstetrics and Women’s Diseases. 2022;71(1):71–78. EDN: MREALK doi: 10.17816/JOWD71360

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附件文件
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1. JATS XML
2. Fig. 1. Somatic and gynecological history chart

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3. Fig. 2. Myoma node sizes

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4. Fig. 3. Somatic changes 1, 3, 6 and 12 months after surgery using the focused ultrasound ablation (a) and uterine artery embolization methods (b)

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