电邮这篇文章 Prognostic significance of mmp-1, mmp-3, and mthfr genetic polymorphism for evaluation of uterine leiomyoma and adenomyosis progression
- 作者: Morozova Е.В.1,2, Chukhlovin А.B.1,2, Kulagina N.V.1,2, Totolian А.А.1,2
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隶属关系:
- State Medical University named after acad. I.P. Pavlova
- Medical Academy of Postgraduate Education
- 期: 卷 54, 编号 3 (2005)
- 页面: 55-59
- 栏目: Original study articles
- URL: https://ogarev-online.ru/jowd/article/view/83482
- DOI: https://doi.org/10.17816/JOWD83482
- ID: 83482
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Carriage of hyperactive alleles of matrix metalloproteinase-1 (MMP-1) gene is associated with enhanced growth of various neoplasias in humans. When studying the frequency of promoter variants of MMP -1 and -3 genes in 170 patients with uterine leiomyoma, significant associations were revealed between low incidence of MMP-1 1G/1G genotype, high growth rates of leiomyoma, multifocal growth and more common adenomyosis development, thus presuming a protective role of MMP-1/1G homozygosity in the development of symptomatic myoma and adenomyosis and growth-promoting effect of the 2G allele. Hence, the promoter genotype of MMP-1 may be considered as possible genetic marker to predict clinical course of the uterine leiomyoma.
作者简介
Е. Morozova
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
编辑信件的主要联系方式.
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
俄罗斯联邦, Saint Petersburg; Saint PetersburgА. Chukhlovin
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
俄罗斯联邦, Saint Petersburg; Saint PetersburgN. Kulagina
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
俄罗斯联邦, Saint Petersburg; Saint PetersburgА. Totolian
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
俄罗斯联邦, Saint Petersburg; Saint Petersburg参考
