Influence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae
- 作者: Zazerskaya I.Е.1, Aseev М.V.1, Kuznetsova L.V.1, Moskalenko М.V.1, Ivashenko Т.Е.1, Baranov V.S.1
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隶属关系:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- 期: 卷 54, 编号 2 (2005)
- 页面: 23-30
- 栏目: Original study articles
- URL: https://ogarev-online.ru/jowd/article/view/81636
- DOI: https://doi.org/10.17816/JOWD81636
- ID: 81636
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Studies on the genetics have focused on the regulation of bone mineral density (BMD) a major predictor of osteoporotic fracture risk. Evidence for a genetic contribution to BMD regulation comes primarily from twin studies — that’s hawed that between 50—70 % of variance in BMD is caused by genetic factors. A great deal of research has been done on gene candidate VDR.3 on 176 postmenopausal women (108 natural menopause and 69 surgical menopause). Polymorphisms of vitamin D receptor have been associated in our group with the speed of bone turnover, registries by DEXA with interval 12 months and DDR test. The every second patient with genotype tt has chance to accompany group with osteoporosis in postmenopausae. In group of women with highs speed of bone turnover frequency t allel in 3 time more than in group with slow bone turnover.
作者简介
I. Zazerskaya
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
编辑信件的主要联系方式.
Email: info@eco-vector.com
俄罗斯联邦, Saint Petersburg
М. Aseev
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
俄罗斯联邦, Saint Petersburg
L. Kuznetsova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
俄罗斯联邦, Saint Petersburg
М. Moskalenko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
俄罗斯联邦, Saint Petersburg
Т. Ivashenko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
俄罗斯联邦, Saint Petersburg
V. Baranov
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
俄罗斯联邦, Saint Petersburg
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