Email this article Ovarian aromatase activity in endometriosis
- Authors: Denisova V.M.1, Potin V.V.1, Yarmolinskaya M.I.1, Timofeyeva Y.M.1
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Affiliations:
- D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
- Issue: Vol 62, No 2 (2013)
- Pages: 17-22
- Section: Articles
- URL: https://ogarev-online.ru/jowd/article/view/2631
- DOI: https://doi.org/10.17816/JOWD62217-22
- ID: 2631
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Abstract
Aromatase is the key enzyme, which converts androgens into estrogens. To study the role of aromatase in pathogenesis of endometriosis 57 patients and 15 healthy women of reproductive age were examined. Aromatase activity was detected by reaction of estrogens on aromatase inhibitor letrozol intake. Ovarian source of detected aromatase activity was proved by suppression of reaction on letrozole intake during therapy with gonadotropin- releasing hormone agonist. Aromatase activity in recalculation on antral follicle in endometriosis patients withII–IV stages was higher than in healthy women, though total ovarian aromatase activity was not differed from control group because of low number of antral follicles in endometriosis patients. The disturbance of folliculogenesis in endometriosis is connected probably with hyperestronaemia, which has ovarian and extragonandal origin.
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##article.viewOnOriginalSite##About the authors
Valentina Mikhaylovna Denisova
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: valyik@mail.ru
Postgraduate
Vladimir Vsevolodovich Potin
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: iagmail@ott.ru
MD, PhD, Honoured figure, professor, Head of Reproductive Ednocrinology Departement
Mariya Igorevna Yarmolinskaya
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: m.yarmolinskaya@gmail.com
MD, Leading Scientific Researcher of the department of reproductive endocrinology
Yekaterina Mikhaylovna Timofeyeva
D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS
Email: katisun@rumbler.ru
Doctor of Clinical Laboratory Diagnostics
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