Email this article Role of adjuvant hormonal therapy in treatment of endometriosis-assosiated infertility
- Authors: Gerkulov D.A.1
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Affiliations:
- I.P. Pavlov First State Medical University of St. Petersburg
- Issue: Vol 64, No 5 (2015)
- Pages: 32-35
- Section: Articles
- URL: https://ogarev-online.ru/jowd/article/view/1321
- DOI: https://doi.org/10.17816/JOWD64532-35
- ID: 1321
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Abstract
Background. In vitro fertilization (IVF) represents the most efficient means of overcoming endometriosis-related infertility. Objective. To investigate the outcomes of in vitro fertilization cycles after controlled ovarian hyperstimulation in patience operated for endometrioma after different adjuvant hormonal therapy. Material and methods. 144 patients with endometriosis-associated infertility undergoing IVF were divided into three groups: GnRH agonist administration; dienogest 2 mg daily administration; women without adjuvant therapy. Results. Сlinical pregnancy rates were 2,5 times higher (44,7 and 16,7 % respectively; p = 0,01) and live birth rate was 3 times higher (36,8 и 11,1 % respectively; p = 0,01) in dienogest administration group before IVF/ICSI cycle in comparison with no adjuvant therapy groups, respectively. Conclusion. Considering the clinical pregnancy and live birth rate rates dienogest administration may be effective in patients with mild-to-moderate endometriosis prior to IVF/ICSI cycle.
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##article.viewOnOriginalSite##About the authors
Dmitriy Alexandrovich Gerkulov
I.P. Pavlov First State Medical University of St. Petersburg
Email: gerkulov@gmail.com
post-graduate student, Department of obstetrics, gynecology and reproductology
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