电邮这篇文章 Genital endometriosis and melatonin: a role in the pathogenesis and its possible use in the treatment of the disease
- 作者: Yarmolinskaya M.I.1,2, Tkhazaplizheva S.S.1, Molotkov A.S.1,3, Tkachenko N.N.1, Borodina V.L.1, Andreyeva N.Y.1, Kleymyonova T.S.1,4, Lysenko V.V.4
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隶属关系:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- orth-Western State Medical University named after I.I. Mechnikov
- aint Petersburg State University
- Saint Petersburg State Pediatric Medical University
- 期: 卷 68, 编号 3 (2019)
- 页面: 51-60
- 栏目: Original study articles
- URL: https://ogarev-online.ru/jowd/article/view/11752
- DOI: https://doi.org/10.17816/JOWD68351-60
- ID: 11752
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详细
Hypothesis/aims of study. Melatonin is found in almost all living organisms, the range of its effects being quite diverse. Effects of this hormone in the human body are realized via two ways, through specific receptors and non-receptor pathways. Melatonin may act through both membrane and nuclear receptors. In the present work, the expression of MTR1 and MTR2 melatonin receptors was studied in the eutopic endometrium and endometrioid heterotopies, and the level of melatonin metabolite, 6-sulfatoxymelatonin, in daily urine in patients with genital endometriosis (GE) was analyzed.
Study design, materials and methods. The experimental group included 67 patients of reproductive age with a verified diagnosis of GE, and the control group consisted of 18 individuals with an ovulatory menstrual cycle without gynecological pathology. The 6-sulfatoxymelatonin level in daily urine was determined by enzyme immunoassay. The study of MTR1 and MTR2 melatonin receptor expression in the endometrium and endometrioid heterotopies was performed in 24 patients with GE and in 10 women of reproductive age who were examined for infertility who did not have gynecological pathology based on diagnostic laparoscopy. To study the expression of melatonin receptors, the endometrium and endometrial heterotopy sampling was carried out from day 18 to day 22 of the menstrual cycle. Morphological assessment included histological and immunofluorescence studies using confocal laser scanning microscopy.
Results. In patients with GE, there was found a tendency to a decrease in 6-sulfatoxymelatonin excretion in daily urine compared to the control group. It was also found that the total relative expression area of melatonin receptors in the endometrium of women with GE was significantly lower compared to the endometrium of patients from the control group. Significant differences between the average brightness and optical density were not found. In addition, it was revealed that the relative expression areas of MTR1 and MTR2 melatonin receptors in the eutopic endometrium and in endometrioid heterotopies did not differ significantly. A negative correlation was stated between the relative expression area of melatonin receptors and GE prevalence. Particular attention is paid to the role of melatonin in the development of GE and to the possibilities of working out new treatment regimens with its use.
Conclusion. The data obtained confirm the undoubted role of melatonin in the pathogenesis of GE, however, the development of new treatment regimens with its use requires further study.
作者简介
Maria Yarmolinskaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; orth-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
MD, PhD, DSci (Medicine), Professor of the Russian Academy of Sciences, the Head of the Department of Endocrinology of Reproduction, the Head of the Diagnostics and Treatment of Endometriosis Center; Professor. The Department of Obstetrics and Gynecology
俄罗斯联邦, Saint PetersburgSaimat Tkhazaplizheva
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: saim86@mail.ru
MD, Post-Graduate Student
俄罗斯联邦, Saint PetersburgArseniy Molotkov
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; aint Petersburg State University
Email: arseny.molotkov@gmail.com
ORCID iD: 0000-0003-3433-3092
SPIN 代码: 6359-6472
MD, PhD, Senior Researcher. The Department of Gynecology with the Operating Unit; Associate Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, Medical Faculty
俄罗斯联邦, Saint PetersburgNatalia Tkachenko
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: liberin@mail.ru
PhD, the Head of the Laboratory of Endocrinology. The Department of Endocrinology of Reproduction
俄罗斯联邦, Saint PetersburgValentina Borodina
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: bvl130250@mail.ru
PhD, Senior Researcher. The Department of Endocrinology of Reproduction
俄罗斯联邦, Saint PetersburgNelli Andreyeva
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: nelly8352@yahoo.com
Clinical Resident
俄罗斯联邦, Saint PetersburgTatyana Kleymyonova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: kleimenovats@gmail.com
ORCID iD: 0000-0003-0767-5564
SPIN 代码: 4876-3420
Junior Researcher. The Laboratory of Cell Biology, the Department of Pathomorphology; Senior Laboratory Assistant. The Department of Medical Biology
俄罗斯联邦, Saint PetersburgVera Lysenko
Saint Petersburg State Pediatric Medical University
Email: verochka.lysenko.96@mail.ru
Student
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